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101. Guidelines for the management of hereditary colorectal cancer

colonoscopy should be performed from age 40 years until age 75 years. (GRADE of evidence: moderate; Strength of recommendation: weak) Prevention & Lifestyle Modification in Familial CRC o We recommend that individuals with LS should be advised that regular use of daily aspirin reduces CRC risk. (GRADE of evidence: moderate; Strength of recommendation: strong) o We suggest that people with LS should be offered research opportunities to take aspirin daily at different dosages. If they decline research (...) participation they may be advised on their choices regarding dose of aspirin, risks and benefits of long-term Aspirin use and ensure their medical practitioner is aware of their intake. (GRADE of evidence: low ; Strength of recommendation: weak) o There is insufficient evidence of the benefit of chemoprophylaxis in polyposis syndromes. (GRADE of evidence: moderate; Strength of recommendation: strong) o We suggest that individuals at increased familial risk of CRC should be strongly encouraged not to smoke

2019 British Society of Gastroenterology

103. Primary prevention of coronary heart disease in women

statement will examine the evidence regarding HRT and non-oestrogen therapies (lipid lowering agents, aspirin, antihypertensives, antidiabetic medications, SERMs) as well as diet, lifestyle and smoking cessation in the primary prevention of CHD in women. Summary practice points oestrogen may have a protective role in CHD prevention especially if initiated in women below age 60 years or within 10 years of onset of menopause women with a premature menopause should take oestrogen to reduce the risk of CHD (...) lipid-lowering agents are probably beneficial in primary prevention aspirin cannot be recommended for primary prevention of CHD, but may protect against stroke treating hypertension reduces the risk of CHD in diabetics, prevention of CHD is based on management of established cardiovascular risk factors through both lifestyle measures and pharmacotherapy in metabolic syndrome, prevention of CHD is based on management of established cardiovascular risk factors through both lifestyle measures

2019 British Menopause Society

104. Stroke, Diagnosis and Initial Treatment of Ischemic Stroke

combination therapy (eg, aspirin and clopidogrel) before stroke on the basis of evidence that the benefit of alteplase outweighs a probable increased risk of sICH. (Class I; LOE B-NR) Agree End-stage renal disease 1. In patients with end-stage renal disease on hemodialysis and normal aPTT, IV alteplase is recommended. (Class I; LOE C-LD) However, those with elevated aPTT may have elevated risk for hemorrhagic complications. Agree Contraindications (Class III) Time of onset 1. IV alteplase

2019 Institute for Clinical Systems Improvement

105. Screening and Management of Bleeding Disorders in Adolescents With Heavy Menstrual Bleeding

. Adolescents in whom a bleeding disorder has been diagnosed should be reminded that products that prevent platelet adhesion, such as aspirin or nonsteroidal antiinflammatory drugs, should be used only with the recommendation of a hematologist. In adolescents with known bleeding disorders, preoperative surgical evaluation, choice of hemostatic agents for control of intraoperative blood loss, and need for blood products should be determined in conjunction with a hematologist and an anesthesiologist (...) be reminded that products that prevent platelet adhesion, such as aspirin or nonsteroidal antiinflammatory drugs, should be used only with the recommendation of a hematologist ( ). Future Gynecologic and Reproductive Health Concerns In adolescents with known bleeding disorders, preoperative surgical evaluation, choice of hemostatic agents for control of intraoperative blood loss, and need for blood products should be determined in conjunction with a hematologist and an anesthesiologist. Vulvovaginal

2019 American College of Obstetricians and Gynecologists

110. Diagnosis and management of acute lower gastrointestinal bleeding

to its short half- life, but in severe life-threatening haemorrhage its effects can be reversed with protamine sulfate. The anticoagulant effect of low molecular weight heparin may persist for 24 hours and prota- mine sulfate is less effective. 11. We suggest that aspirin for primary prophylaxis of cardio- vascular events should be permanently discontinued (weak recommendation, low quality evidence). 12. We recommend that aspirin for secondary prevention is not routinely stopped. If it is stopped (...) , although there was no associated increase in interventions to treat bleeding or mortality. 112 Aspirin irreversibly inhibits the function of platelets for their lifespan (5–7 days). Its effect on endothelial prostaglandin synthesis is, however, much shorter, and there may be benefits in temporarily stopping aspirin if severe haemorrhage occurs. In patients receiving single antiplatelet agents most rebleeding occurs within 5 days of the index event. 112 The risk: benefit anal- ysis of discontinuing

2019 British Society of Gastroenterology

112. Management of Stroke in Neonates and Children Full Text available with Trip Pro

and anemia. Antiplatelet therapy such as aspirin and anticoagulation with low-molecular-weight heparin (LMWH) or unfractionated heparin (UFH) is rarely indicated because of the low risk of recurrent stroke after neonatal AIS; however, it must be considered in those exceptional neonates with high risk of recurrent AIS resulting from documented thrombophilia or complex congenital heart disease (not including patent foramen ovale [PFO]). , Hyperacute stroke therapies (thrombolytics and mechanical (...) the eventual outcome. Ventricular drainage and, if indicated, later shunting for progressive hydrocephalus resulting from IVH is appropriate. Considerations for Clinical Practice Vitamin K should be routinely administered to newborns. Larger doses of vitamin K may be needed to correct factor deficiencies resulting from maternal medications. Aspirin, LMWH, or UFH may be considered in neonates at risk for stroke recurrence because of severe thrombophilia or cerebral embolism resulting from cardiac disease

2019 American Heart Association

114. Treatment of Hypertension in Association With Diabetes Mellitus

and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998;351:1755-62. Patel A, MacMahon S, Chalmers J, et al. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): A randomised controlled trial. Lancet 2007;370:829-40. PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood-pressure

2018 Hypertension Canada

115. Goals of Therapy for Adults With Hypertension Without Compelling Indications for Specific Agents

:1955-64. Hansson L, Zanchetti A, Carruthers SO, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998;351:1755-62. UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMAJ 1998;317:703-13 . Estacio R, Jeffers B, Hiatt W, et al. The effect of nisoldipine

2018 Hypertension Canada

116. Treatment of Hypertension in Association With Stroke

to delineate an appropriate SBP target, if an, above 140 mmHg. All trials to date have followed the convention in limiting SBP increases beyond 180 mmHg in their control arms. References International Stroke Trial Collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19,435 patients with acute ischaemic stroke. Lancet 1997; 349:1569-81. Ahmed N, Na ̈sman P, Wahlgren NG. Effect of intravenous nimodipine on blood pressure (...) . Diener HC, Sacco RL, Yusuf S, et al., for the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol 2008 Oct;7(10):875-84. doi: 10.1016/S1474

2018 Hypertension Canada

117. Global Vascular Protection Therapy for Adults with Hypertension Without Compelling Indications for Specific Agents

, Zanchetti A, Carruthers SG, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet 1998;351:1755-62. Hansson L, Zanchetti A; for the HOT Study Group. The hypertension optimal treatment study (the HOT study). Blood Press 1993;2:62-8. Hackam DG, Quinn RR, Ravani P, et al. The 2013 Canadian Hypertension Education Program recommendations for blood pressure (...) measurement, diagnosis, and assessment of risk, prevention, and treatment of hypertension. Can J Cardiol 2013;29:528-42. Calonge N, Petitti DB, DeWitt TG, Gordis L. Aspirin for the prevention of cardiovascular disease: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2009;150:396-404. Rothwell PM, Fowkes FG, Belch JF, et al. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 2011;377:31-41

2018 Hypertension Canada

118. Choice of therapy for Adults With Hypertension Without Compelling Indications for Specific Agents

in China), Kong D, et al. Shanghai trial of nifedipine in the elderly. J Hypertens 1996;14:1-9. Medical Research Council Working Parry. MRC trial of treatment of hypertension: principal results. Br Med J (Clin Res Ed) 1985 Jul 13;291(6488):97-104. MRC Working Party. Medical Research Council trial of treatment of hypertension in older adults: principal results. BMJ 1992;304:405-12. Hansson L, Zanchetti A, Carruthers SO, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients

2018 Hypertension Canada

119. Treatment of Hypertension in Association With Ischemic Heart Disease

between diastolic blood pressure and severity of coronary artery lesion in hypertensive patients with angina pectoris. Hypertens Res 2002;25:381-7. Hansson L, Zanchetti A, Carruthers SG, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998;351:1755-62. ©2015 . All rights reserved. Unauthorized use prohibited. Hypertension Canada does not provide medical advice

2018 Hypertension Canada

120. Diagnosis & Assessment of Hypertension - Assessing CV Risk

blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet 1998;351:1755-62. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group. BMJ 1998;317:703-13.. Estacio RO, Jeffers BW, Gifford N, Schrier RW. Effect of blood pressure control on diabetic microvascular complications

2018 Hypertension Canada

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