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21. Hyperacute stroke management. Acute ASA therapy. In: Canadian best practice recommendations for stroke care.

Hyperacute stroke management. Acute ASA therapy. In: Canadian best practice recommendations for stroke care. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund You are here Guidelines

2010 Canadian Stroke Network

22. Colorectal cancer

(including off-label use), professional guidelines, standards and laws (including on consent and mental capacity), and safeguarding. 1.1 1.1 Prevention Prevention of colorectal cancer in people with of colorectal cancer in people with Lynch syndrome Lynch syndrome 1.1.1 Consider daily aspirin [1] , to be taken for more than 2 years, to prevent colorectal cancer in people with Lynch syndrome. T o find out why the committee made the recommendation on prevention of colorectal cancer in people with Lynch (...) or no preoperative treatment, offer: capecitabine in combination with oxaliplatin (CAPOX) for 3 months, or if this is not suitable oxaliplatin in combination with 5-fluorouracil and folinic acid (FOLFOX) for 3 to 6 months, or single-agent fluoropyrimidine (for example, capecitabine) for 6 months, in line with NICE technology appraisal guidance (see adjuvant treatment of stage III colon cancer in the NICE Pathway on colorectal cancer). Base the choice on the person's histopathology (for example pT1-T3 and pN1

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

23. Venous thromboembolic diseases: diagnosis, management and thrombophilia testing

of 47antiphospholipid syndrome or extreme body weight (less than 50 kg or more than 120 kg), consider carrying on with the current treatment if it is well tolerated. [2020] [2020] 1.4.10 If anticoagulation treatment fails follow the recommendation on treatment failure. [2020] [2020] 1.4.11 For people who decline continued anticoagulation treatment, consider aspirin 75 mg or 150 mg daily [6] . [2020] [2020] 1.4.12 Review general health, risk of VTE recurrence, bleeding risk and treatment preferences at least once (...) a year for people taking long-term anticoagulation treatment or aspirin. [2020] [2020] For a short explanation of why the committee made the 2020 recommendations on reviewing anticoagulation treatment and how they might affect practice, see rationale and impact. Full details of the evidence and the committee's discussion are in: • evidence review F: what factors determine the optimum duration of pharmacological treatment for DVT or PE in people with a VTE? • evidence review D: pharmacological

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

24. Twin and triplet pregnancy

pregnancy compared with women with a singleton pregnancy. [2011] [2011] 1.2.4 Perform a full blood count at 20 to 24 weeks to identify women with a twin or triplet pregnancy who need early supplementation with iron or folic acid (this is in addition to the test for anaemia at the routine booking appointment recommended in NICE's guideline on antenatal care for uncomplicated pregnancies). Repeat at 28 weeks as in routine antenatal care. [2011] [2011] 1.3 Delivery of antenatal and intrapartum care (...) on antenatal care for uncomplicated pregnancies. [2011] [2011] 1.6.2 Advise women with a twin or triplet pregnancy to take low-dose aspirin [1] daily from 12 weeks until the birth of the babies if they have 2 or more of the risk factors specified in NICE's guideline on hypertension in pregnancy. [2011, [2011, amended 2019] amended 2019] Twin and triplet pregnancy (NG137) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 20

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

25. Hypertension in pregnancy: diagnosis and management

-eclampsia. [2010, amended 2019] [2010, amended 2019] Antiplatelet agents Antiplatelet agents 1.1.2 Advise pregnant women at high risk of pre-eclampsia to take 75–150 mg of aspirin [1] daily from 12 weeks until the birth of the baby. Women at high risk are those with any of the following: hypertensive disease during a previous pregnancy chronic kidney disease autoimmune disease such as systemic lupus erythematosus or antiphospholipid Hypertension in pregnancy: diagnosis and management (NG133) © NICE 2019 (...) . All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 6 of 54syndrome type 1 or type 2 diabetes chronic hypertension. [2010, amended 2019] [2010, amended 2019] 1.1.3 Advise pregnant women with more than 1 moderate risk factor for pre- eclampsia to take 75–150 mg of aspirin [1] daily from 12 weeks until the birth of the baby. Factors indicating moderate risk are: first pregnancy age 40 years or older pregnancy interval of more than

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

26. Ulcerative colitis: management

should follow relevant professional guidance, taking full responsibility for the decision. Informed consent should be obtained and documented. See the General Medical Council's Prescribing guidance: prescribing unlicensed medicines for further information. [3] At the time of publication (May 2019), beclometasone dipropionate only has a UK marketing authorisation 'as add-on therapy to 5-ASA containing drugs in patients who are non-responders to Ulcerative colitis: management (NG130) © NICE 2019. All (...) rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 17 of 285-ASA therapy in active phase' . Additionally, budesonide (oral or rectal) and prednisolone foam are not licensed in children. For use outside these licensed indications, the prescriber should follow relevant professional guidance, taking full responsibility for the decision. Informed consent should be obtained and documented. See the General Medical Council's Prescribing

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

27. Stroke and transient ischaemic attack in over 16s: diagnosis and initial management

1.7 Optimal positioning and early mobilisation for people with acute stroke 16 1.8 Avoiding aspiration pneumonia 17 1.9 Surgery for people with acute stroke 17 T erms used in this guideline 18 Recommendations for research 21 Key recommendations for research 21 Rationale and impact 22 Initial management of suspected and confirmed transient ischaemic attack (aspirin) 22 Initial management of suspected and confirmed transient ischaemic attack 22 Imaging for people who have had a suspected TIA (...) to the emergency department with a suspected stroke or TIA, establish the diagnosis rapidly using a validated tool, such as ROSIER (Recognition of Stroke in the Emergency Room). [2008] [2008] Initial management of suspected and confirmed TIA Initial management of suspected and confirmed TIA 1.1.4 Offer aspirin (300 mg daily), unless contraindicated, to people who have had a suspected TIA, to be started immediately. [2019] [2019] 1.1.5 Refer immediately people who have had a suspected TIA for specialist

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

28. COVID-19 recommendations during airway manipulation

/situation-reports/) 2. https://www.cdc.gov/coronavirus/2019-ncov/infection-control/control- recommendations.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F201 9-ncov%2Fhcp%2Finfection-control.html 3. https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus- infection.html 4. (https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory- infection-when-novel-coronavirus-(ncov)-infection-is-suspected 5. https://www.asahq.org/about-asa (...) /governance-and-committees/asa-committees/committee- on-occupational-health/coronavirus 6. https://www.apsf.org/news-updates/perioperative-considerations-for-the-2019-novel- coronavirus-COVID-19/ 7. Br J Anaesth. 2020 Feb 27. pii: S0007-0912(20)30098-2. doi: 10.1016/j.bja.2020.02.008. [Epub ahead of print] 8. Lancet Respir Med. 2020 Feb 24. pii: S2213-2600(20)30084-9. doi: 10.1016/S2213- 2600(20)30084-9. [Epub ahead of print] 9. Caputo KM, Byrick R, Chapman MG, Orser BJ, Orser BA (2006) Intubation of SARS

2020 CPG Infobase

29. Management of thin endometrium in assisted reproduction: a clinical practice guideline from the Canadian Fertility and Andrology Society Full Text available with Trip Pro

for frozen embryo transfers. In patients with thin endometrium undergoing embryo transfer cycles, we suggest against the use of aspirin to improve pregnancy rates. Weak ⊕○○○ No effect in one small RCT. In patients with thin endometrium undergoing fresh IVF-embryo transfer cycles, we suggest against the use of luteal oestradiol to improve pregnancy rates. Weak ⊕○○○ No benefit seen in one small observational study. In patients with thin endometrium undergoing embryo transfer cycles, there is insufficient (...) ., Wang, Y., Li, Y. 2014. Endometrial pattern, thickness and growth in predicting pregnancy outcome following 3319 IVF cycle. Reprod Biomed Online 29:291–298. Table 3 Summary of findings: aspirin compared with no treatment for patients with thin endometrium undergoing IVF-embryo transfer (fresh or frozen) Outcomes Anticipated absolute effects a The risk in the intervention group (and 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and 95% CI

2020 CPG Infobase

30. Sore throat (acute): antimicrobial prescribing

medicines, unless otherwise stated. 3 Erythromycin is preferred in young women who are pregnant. See the evidence and committee discussion on choice of antibiotic and antibiotic course length. Sore throat (acute): antimicrobial prescribing (NG84) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 9 of 24Summary of the e Summary of the evidence vidence Self-care Or Oral analgesia al analgesia Overall aspirin, paracetamol (...) and diclofenac potassium (not available to buy over the counter) were all more effective than placebo at reducing pain and fever in adults with sore throat associated with an upper respiratory tract infection. This was based on low to moderate quality evidence from 3 randomised controlled trials (RCTs) (Eccles et al. 2003, Gehanno et al. 2003 and Voelker et al. 2016). Overall, adverse events for aspirin, paracetamol and diclofenac potassium in the 3 RCTs did not appear to be significantly different from

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

31. Rheumatoid arthritis in adults: management

, including age and pregnancy. [2018] [2018] 1.6.2 When treating symptoms of RA with oral NSAIDs: offer the lowest effective dose for the shortest possible time offer a proton pump inhibitor (PPI), and and review risk factors for adverse events regularly. [2018] [2018] 1.6.3 If a person with RA needs to take low-dose aspirin, healthcare professionals should consider other treatments before adding an NSAID (with a PPI) if pain relief is ineffective or insufficient. [2009, amended 2018] [2009, amended 2018

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

32. Dementia: assessment, management and support for people living with dementia and their carers

-steroidal anti-inflammatory drugs (NSAIDs), including aspirin. Pharmacological management of non-Alzheimer's dementia Pharmacological management of non-Alzheimer's dementia 1.5.10 Offer donepezil or rivastigmine to people with mild to moderate dementia with Lewy bodies. [1] 1.5.11 Only consider galantamine [2] for people with mild to moderate dementia with Lewy bodies if donepezil and rivastigmine [1] are not tolerated. 1.5.12 Consider donepezil or rivastigmine for people with severe dementia with Lewy

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

33. Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolism

for people who are obese 35 Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolism (NG89) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 413 Direct oral anticoagulants for people with lower limb immobilisation 36 4 Aspirin prophylaxis for people with fragility fractures of the pelvis, hip or proximal femur 37 5 Duration of prophylaxis for elective total (...) 2018] Pharmacological proph Pharmacological prophylaxis ylaxis 1.3.12 For pharmacological VTE prophylaxis in people under 18, follow the recommendations on apixaban, aspirin, dabigatran etexilate, fondaparinux sodium, low-molecular-weight heparin (LMWH) and rivaroxaban in this guideline. At the time of publication (March 2018), these drugs did not have a UK marketing authorisation for use in young people under 18 for this indication. The prescriber should follow relevant professional guidance

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

35. Kidney Pre-biopsy medication: Antiplatelet and anticoagulant agents

).tw. 21 (acute kidney injur$ or acute renal injur$).tw. 22 (acute kidney insufficie$ or acute renal insufficie$).tw. 23 acute tubular necrosis.tw. 24 (ARI or AKI or ARF or AKF or ATN).tw. 25 or/1-24 26 renal biopsy.mp. 27 exp kidney biopsy/ 28 renal biops$.tw. 29 kidney biops$.tw. 30 26 or 27 or 28 or 29 31 25 and 30 32 exp thrombocyte/ or exp acetylsalicylic acid/ or exp dipyridamole/ or exp dual antiplatelet therapy/ or exp clopidogrel/ or exp antithrombocytic agent/ or exp ticlopidine/ 33 (...) MacGinley. GUIDELINES a. We recommend continuation of aspirin in patients at high risk for a cardiovascular event, including those with a history of coronary stent (particularly within 3 months of bare metal stent or 12 months of drug eluting stent insertion), symptomatic myocardial ischaemia or peripheral vascular disease (including patients with a peripheral stent), or previous ischaemic stroke (1C). b. We recommend cessation of aspirin for patients at low risk for a cardiovascular event either 3 days

2020 KHA-CARI Guidelines

36. Kidney Pre-biopsy medication: Desmopressin acetate

) ___________________________________________________________________________________________________________________________________________________________________________________________________ Renal Biopsy - Desmopressin Acetate July 2018 Page 9 of 11 Table 6. Thrombosis and other outcomes Study ID N Study type Intervention Control Outcome Results Quality Ensat et al (2013)(20) 1 Case report 4mcg desmopressin given 5 days post-op for diabetes insipidus. N/A Thrombosis ? Skin island showed signs of venous congestion within one hour of desmopressin administration. ? Thrombectomy performed and patient was treated with low molecular heparin and acetylsalicylic acid. Further healing

2020 KHA-CARI Guidelines

37. Recommendations for good practice in Ultrasound: Oocyte retrieval Full Text available with Trip Pro

and take actions to prevent any possible associated complications. Patients should at least be asked about the use of medications—more specifically the use of blood thinning agents (aspirin and others), relevant previous surgeries and any relevant disease or deficit of coagulation factors. Information provision and informed consent – Recent or confirmation of (written) informed consent for treatment should be obtained according to local regulations. Verbal and written information should be provided

2020 European Society of Human Reproduction and Embryology

38. The Australian and New Zealand Intensive Care Society (ANZICS) COVID-19 Guidelines

Tan Dr Allen Cheng (President Elect, Australasian Society for Infectious Diseases) Dr Winston Cheung A/Prof Jeremy Cohen, (College of Intensive Care Medicine Representative) Dr Alan Davey-Quinn Dr Graeme Duke Dr Simon Erickson Dr Marino Festa A/Prof Ross Freebairn A/Prof Craig French Dr Geoff Gordon Dr Simon Iles A/Prof Nerina Harley Dr Daniel Holmes, ASA Representative Dr Veerendra Jagarlamudi Dr Pierre Janin Dr Barry Johnston Dr Ed Litton Connecting the Intensive Care Community Australian

2020 Covid-19 Ad hoc guidelines

39. Guidance for maternal medicine in the evolving coronavirus (COVID-19) pandemic

for protein: creatinine ratio (urinary PCR) with the booking bloods. The obstetric team should first review the woman at 10-14 weeks by remote consultation (or in person if aligned with an 11-13 weeks’ scan). This review should assess the risk status, plan care and ensure that the woman is aware of how to access prescriptions for antihypertensive medication and low-dose aspirin. Arrange for the woman to self-monitor her blood pressure where possible and, if indicated, to check urine dipstick (...) cholestasis The following guidance has been adapted from the peer-reviewed but unpublished update to the RCOG Green-top Guideline on Obstetric Cholestasis (OC). If a pregnant woman presents with itching, and no other red flag symptoms or signs, offer a non-fasting blood sample for liver transaminases and bile acids, which could be done in the community. Assess fetal wellbeing by asking the woman about fetal movements. Additional fetal scans or cardiotocographs (CTGs) are not indicated by OC alone

2020 Royal College of Obstetricians and Gynaecologists

40. Clinical care of severe acute respiratory infections – Tool kit

protocol. Black or bloody vomit or stool Stomach or intestinal bleeding Rapid or deep breathing, dehydration, high glucose, sweet- smelling breath, history of frequent urination or known diabetes Diabetic ketoacidosis Burns Severe uid loss (calculate uid needs based on burn size) Fever or HIV Infection Recent fall or other trauma Internal AND external bleeding Pale conjunctiva or malnutrition Severe anemia (adjust uids) Chest pain Heart attack (give aspirin if indicated) Vaginal bleeding Pregnancy

2020 WHO Coronavirus disease (COVID-19) Pandemic

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