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41. Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribing

implications 24 Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribing (NG114) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 24This guideline should be read in conjunction with NG115. Ov Overview erview This guideline sets out an antimicrobial prescribing strategy for acute exacerbations of chronic obstructive pulmonary disease (COPD). It aims to optimise antibiotic use and reduce (...) antibiotic resistance. See a 2-page visual summary of the recommendations, including tables to support prescribing decisions. See the NICE guideline on COPD in over 16s for other recommendations on preventing and managing an acute exacerbation of COPD, including self-management. Who is it for? Health professionals People with COPD, their families and carers Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribing (NG114) © NICE 2019. All rights reserved. Subject to Notice

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

42. Prostatitis (acute): antimicrobial prescribing

is it for? 4 Recommendations 5 1.1 Managing acute prostatitis 5 1.2 Self-care 6 1.3 Choice of antibiotic 7 Summary of the evidence 9 Self-care 9 Antibiotics 9 Choice of antibiotic 11 Antibiotic course length 14 Antibiotic prophylaxis for preventing infective complications, including acute prostatitis, after biopsy 16 Other considerations 17 Medicines adherence 17 Resource implications 17 Prostatitis (acute): antimicrobial prescribing (NG110) © NICE 2019. All rights reserved. Subject to Notice of rights (...) (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 17Ov Overview erview This guideline sets out an antimicrobial prescribing strategy for acute prostatitis. It aims to optimise antibiotic use and reduce antibiotic resistance. See a 2-page visual summary of the recommendations, including a table to support prescribing decisions. NICE has also produced a guideline on antimicrobial stewardship: systems and processes for effective antimicrobial medicine use. Who is it for? Health

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

43. Urinary tract infection (lower): antimicrobial prescribing

of 35Contents Contents Overview 4 Who is it for? 4 Recommendations 5 1.1 Managing lower urinary tract infection 5 1.2 Managing asymptomatic bacteriuria 8 1.3 Self-care 9 1.4 Choice of antibiotic 9 Summary of the evidence 15 Self-care 15 Antibiotics 16 Choice of antibiotic 23 Antibiotic course length 29 Other considerations 34 Medicines adherence 34 Resource implications 34 Update information 35 Urinary tract infection (lower): antimicrobial prescribing (NG109) © NICE 2019. All rights reserved. Subject (...) to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 35This guideline should be read in conjunction with CG54, NG111 and NG112. Ov Overview erview This guideline sets out an antimicrobial prescribing strategy for lower urinary tract infection (also called cystitis) in children, young people and adults who do not have a catheter. It aims to optimise antibiotic use and reduce antibiotic resistance. See a 3-page visual summary of the recommendations, including

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

44. Pyelonephritis (acute): antimicrobial prescribing

is it for? 4 Recommendations 5 1.1 Managing acute pyelonephritis 5 1.2 Self-care 7 1.3 Choice of antibiotic 7 Summary of the evidence 13 Self-care 13 Antibiotics 13 Choice of antibiotic 14 Antibiotic course length 21 Antibiotic dose frequency 23 Antibiotic route of administration 23 Other considerations 25 Medicines adherence 25 Resource implications 25 Pyelonephritis (acute): antimicrobial prescribing (NG111) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms (...) -and- conditions#notice-of-rights). Page 3 of 26This guideline should be read in conjunction with NG109, NG112 and CG54. Ov Overview erview This guideline sets out an antimicrobial prescribing strategy for acute pyelonephritis (upper urinary tract infection) in children, young people and adults who do not have a catheter. It aims to optimise antibiotic use and reduce antibiotic resistance. See a 3-page visual summary of the recommendations, including a table to support prescribing decisions. NICE has also

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

45. Urinary tract infection (recurrent): antimicrobial prescribing

a catheter. It aims to optimise antibiotic use and reduce antibiotic resistance. See a 2-page visual summary of the recommendations, including a table to support prescribing decisions. NICE has also produced a guideline on antimicrobial stewardship: systems and processes for effective antimicrobial medicine use. Who is it for? Health professionals People with recurrent urinary tract infection, their families and carers Urinary tract infection (recurrent): antimicrobial prescribing (NG112) © NICE 2019 (...) and over people with recurrent upper UTI people with recurrent lower UTI when the underlying cause is unknown pregnant women children and young people under 16 years in line with the NICE guideline on urinary tract infection in under 16s people with suspected cancer in line with the NICE guideline on suspected cancer: recognition and referral. See the evidence and committee discussion on antibiotic prophylaxis. Urinary tract infection (recurrent): antimicrobial prescribing (NG112) © NICE 2019. All

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

46. Antimicrobial and Immunomodulatory Therapy in Adult Patients with COVID-19

Antimicrobial and Immunomodulatory Therapy in Adult Patients with COVID-19 British Columbia COVID19 Therapeutics Committee (CTC) Clinical Practice Guidance for Antimicrobial and Immunomodulatory Therapy in Adult Patients with COVID-19 SEVERITY OF ILLNESS ANTIVIRAL THERAPY ANTIBACTERIAL THERAPY IMMUNOMODULATORY THERAPY Critically Ill Patients Hospitalized, ICU-based Patients requiring ventilatory and/or circulatory support; also includes patients requiring high-flow nasal cannula, or higher (...) for DVT prophylaxis Chloroquine or hydroxychloroquine (with or without azithromycin) is not recommended outside of approved clinical trials or where other indications would justify its use Lopinavir/ritonavir is not recommended outside of approved clinical trials Remdesivir* is not recommended outside of approved clinical trials Antibacterial therapy is not routinely recommended outside of approved clinical trials or where other indications would justify its use (eg. suspected bacterial co-infection

2020 Covid-19 Ad hoc guidelines

47. Antimicrobial stewardship: changing risk-related behaviours in the general population

Behavioural strategies and programmes 42 3 High-risk groups 42 4 Workplace 43 5 Older people in day and residential care 43 Antimicrobial stewardship: changing risk-related behaviours in the general population (NG63) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 4 of 44Ov Overview erview This guideline covers making people aware of how to correctly use antimicrobial medicines (including antibiotics) and the dangers (...) section on NHS Choices] or there is a high risk of travellers' diarrhoea). The following recommendations are for local authority public health teams. 1.2.4 Consider linking to awareness-raising initiatives for the public on reducing inappropriate antimicrobial demand and use and antimicrobial resistance (for example, European Antibiotic Awareness Day and Public Health England's Antibiotic Guardian). 1.2.5 Use opportunities that may arise through other local authority activities to distribute

2017 National Institute for Health and Clinical Excellence - Clinical Guidelines

48. Sinusitis (acute): antimicrobial prescribing

Background 5 Recommendations 6 1.1 Managing acute sinusitis 6 1.2 Choice of antibiotic 8 1.3 Self-care 10 Symptoms and signs 12 Common symptoms and signs 12 Factors that might make a bacterial cause more likely 12 Summary of the evidence 13 Self-care 13 Nasal corticosteroids 14 No antibiotic 15 Back-up antibiotics 17 Choice of antibiotic 18 Antibiotic course length 21 Other considerations 23 Medicines adherence 23 Resource implications 23 Sinusitis (acute): antimicrobial prescribing (NG79) © NICE 2019 (...) . All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 24Ov Overview erview This guideline sets out an antimicrobial prescribing strategy for acute sinusitis. It aims to limit antibiotic use and reduce antimicrobial resistance. Acute sinusitis is usually caused by a virus, lasts for about 2 to 3 weeks, and most people get better without antibiotics. Withholding antibiotics rarely leads to complications. See a 2-page visual

2017 National Institute for Health and Clinical Excellence - Clinical Guidelines

49. Infectious Diseases Society of America Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections

, antimicrobial resistant pathogens caused more than 2.8 million infections and over 35,000 deaths annually in the United States from 2012 through 2017, according to the 2019 Centers for Disease Control and Prevention (CDC) Antibiotic Resistant Threats Report [2]. The selection of effective antibiotics for the treatment of infections by resistant pathogens is challenging [3]. Although there has been an increase in the availability of novel antibiotics to combat resistant infections in recent years [3 (...) will be disseminated on multiple platforms and updated as new data emerge. Treatment of antimicrobial resistant Gram-negative bacterial infections was chosen as the initial topic for a guidance document. The overarching goal of this guidance document is to assist clinicians – including those with and without infectious diseases expertise – in selecting antibiotic therapy for infections caused by ESBL-E, CRE, and DTR- P. aeruginosa . Future iterations of this document will address other resistant pathogens

2020 Infectious Diseases Society of America

50. Neonatal infection: antibiotics for prevention and treatment

Neonatal infection: antibiotics for prevention and treatment Neonatal infection ( Neonatal infection (early onset): early onset): antibiotics for pre antibiotics for prev vention and treatment ention and treatment Clinical guideline Published: 22 August 2012 nice.org.uk/guidance/cg149 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guideline (...) inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with complying with those duties. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Neonatal infection (early onset): antibiotics for prevention and treatment (CG149) © NICE 2018. All rights reserved. Subject to Notice of rights (https

2012 National Institute for Health and Clinical Excellence - Clinical Guidelines

51. Prophylactic antibiotics for children with recurrent urinary tract infections

Prophylactic antibiotics for children with recurrent urinary tract infections Prophylactic antibiotics for urinary tract infections are no longer routinely recommended. A large number of children must be given prophylaxis to prevent one infection and antibiotic resistance is a major concern when treating community-acquired urinary tract infections. The results of three recent significant studies are examined, with focus on the efficacy of prophylaxis, and recommendations are made. Key Words (...) : Antibiotic resistance; Antibiotic stewardship; Renal scarring; UTI; VUR

2015 Canadian Paediatric Society

52. Antibiotic Prophylaxis in Breast Surgery

Antibiotic Prophylaxis in Breast Surgery IntroductIon In the UK, there is no consensus on antibiotic prophylaxis in breast surgery. There is variability amongst breast units in the use of, choice and duration of prophylaxis for breast surgery procedures. Trust level guidelines for antibiotic prophylaxis are often derived from general surgery operations. Often no specific consideration is given to breast surgery procedures, which are thought of as “clean surgery” . However the implications (...) of surgical site infections (SSI) in this cohort including delay to the commencement of adjuvant treatments and loss of implants are potentially serious. The incidence of SSIs for breast cancer procedures ranges between 3-15% 3 with women having immediate breast reconstruction at even higher risk of SSI 3 exceeding 20% 4 . This document attempts to balance the trade off between the increased risk of antibiotic resistance for the general population and the increased risks of Clostridium Difficile infection

2015 Association of Breast Surgery

56. Rosacea : Oral antibiotics

Rosacea : Oral antibiotics Oral antibiotics | Prescribing information | Rosacea | CKS | NICE Search CKS… Menu Oral antibiotics Rosacea : Oral antibiotics Last revised in June 2020 Oral antibiotics Doxycycline Contraindications and cautions Do not prescribe doxycycline to people: Who are pregnant or breastfeeding women — tetracyclines are deposited in the teeth and growing bones of the unborn or developing child, which can result in discolouration of teeth and occasionally dental hypoplasia (...) : Dyspnoea, hypotension, peripheral oedema, tachycardia (common). Gastrointestinal disturbances, such as nausea, vomiting, and diarrhoea (uncommon). Antibiotic-associated colitis, anxiety, arthralgia, flushing, increased intracranial pressure with papilloedema, myalgia, severe skin reactions, skin hyperpigmentation (long-term use), tinnitus, vision disorders (rare). Stop treatment and seek medical advice if the person develops severe headache and/or visual disturbance that may suggest benign intracranial

2016 NICE Clinical Knowledge Summaries

57. Implementing an Antibiotic Stewardship Program

Implementing an Antibiotic Stewardship Program Practice Guidelines Search Search Practice Guidelines Practice guidelines are systematically developed statements to assist practitioners and patients in making decisions about appropriate health care for specific clinical circumstances. Attributes of good guidelines include validity, reliability, reproducibility, clinical applicability, clinical flexibility, clarity, multidisciplinary process, review of evidence, and documentation. [Institute

2016 Infectious Diseases Society of America

58. Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High-Value Care From the American College of Physicians and the Centers for Disease Control and Prevention Full Text available with Trip Pro

Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High-Value Care From the American College of Physicians and the Centers for Disease Control and Prevention Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults | Annals of Internal Medicine | American College of Physicians '); } Sign in below to access your subscription for full content INDIVIDUAL SIGN IN | You will be directed to acponline.org to register and create your Annals account (...) INSTITUTIONAL SIGN IN | | Subscribe to Annals of Internal Medicine . You will be directed to acponline.org to complete your purchase. Search Clinical Guidelines | 15 March 2016 Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High-Value Care From the American College of Physicians and the Centers for Disease Control and Prevention Free Aaron M. Harris, MD, MPH; Lauri A. Hicks, DO; Amir Qaseem, MD, PhD, MHA; for the High Value Care Task Force of the American College

2016 American College of Physicians

59. Intra-Operative Surgical Irrigation of the Surgical Incision: What Does the Future Hold?Saline, Antibiotic Agents, or Antiseptic Agents? Full Text available with Trip Pro

Intra-Operative Surgical Irrigation of the Surgical Incision: What Does the Future Hold?Saline, Antibiotic Agents, or Antiseptic Agents? Intra-Operative Surgical Irrigation of the Surgical Incision: What Does the Future Hold—Saline, Antibiotic Agents, or Antiseptic Agents? | Surgical Infections

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