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161. Cardioembolic stroke: everything has changed Full Text available with Trip Pro

Cardioembolic stroke: everything has changed Historically, because of the difficulty of using warfarin safely and effectively, many patients with cardioembolic stroke who should have been anticoagulated were instead given ineffective antiplatelet therapy (or no antithrombotic therapy). With the arrival of new oral anticoagulants that are not significantly more likely than aspirin to cause severe haemorrhage, everything has changed. Because antiplatelet agents are much less effective (...) fibrillation, and that B vitamins (folic acid and B12) do prevent stroke by lowering homocysteine. However, with regard to B12, methylcobalamin should probably be used instead of cyanocobalamin. Many important considerations for judicious application of therapies to prevent cardioembolic stroke are discussed.

2018 Stroke and vascular neurology

162. Comorbidities in Argentine patients with axial spondyloarthritis: Is nephrolithiasis associated with this disease? Full Text available with Trip Pro

(ASAS) 2009 criteria for patients with ax-SpA belonging to the ESPAXIA cohort ("Estudio de eSPondiloartritis Axial Irep Argentina") were included. Data regarding sociodemographics, comorbidities, and disease characteristics were recorded. Statistical analysis included descriptive statistics using the student t-test, Chi-square, and Fisher's exact test. Multiple logistic regression analysis was performed. A p value <0.05 was considered significant.In total, 86 patients were included, 80% were males

2018 European journal of rheumatology

163. Pre-emptive ketorolac for prevention of intraoperative shoulder pain in patients undergoing cesarean section: A double blind randomized clinical trial. Full Text available with Trip Pro

in patients undergoing cesarean section.Two hundred ASA I and II patients scheduled to undergo elective cesarean section under spinal anesthesia were randomized to receive either intravenous ketorolac 30 mg (ketorolac group) or normal saline (control group). The primary outcome was the incidence of intraoperative shoulder pain. Secondary outcomes were severity of intraoperative shoulder pain, amount of intraoperative blood loss, incidence of hypotension, bradycardia and request for intraoperative rescue

2018 Asian journal of anesthesiology Controlled trial quality: predicted high

164. Effect of quercetin on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease. (Abstract)

, aspirin) patients with CHD were randomized into 2 groups - the research group (30 people) and the comparison group (55 people). Quercetin at a dose of 120 mg per os daily was added to standard treatment of the patients of the research group (with CHD), patients of the comparison group continued receiving the same treatment. The day before randomization and 2 months after prescribing differentiation therapy to the patients, echocardiography (echo) and 24 hour Holter ECG monitoring were made.Clinical

2018 Wiadomosci lekarskie (Warsaw, Poland : 1960) Controlled trial quality: uncertain

165. Risk of recurrent venous thromboembolism according to baseline risk factor profiles Full Text available with Trip Pro

Risk of recurrent venous thromboembolism according to baseline risk factor profiles The optimal duration of anticoagulation for venous thromboembolism (VTE) is uncertain. In this prespecified analysis, we used data from 2 randomized trials, which compared once-daily rivaroxaban (20 mg or 10 mg) with aspirin (100 mg) or placebo for extended VTE treatment to estimate the risk of recurrence according to baseline risk factor profiles. Index VTE events were centrally classified as unprovoked (...) , or provoked by major transient or persistent, or minor transient or persistent risk factors, and rates of recurrence at 1 year were calculated. A total of 2832 patients received rivaroxaban; 1131 received aspirin, and 590 received placebo. With unprovoked VTE, rates of recurrence in the 1173 patients given rivaroxaban, the 468 given aspirin, and the 243 given placebo were 2.0%, 5.9%, and 10.0%, respectively. There were no recurrences in patients with VTE provoked by major transient risk factors. With VTE

2018 Blood advances Controlled trial quality: predicted high

166. Comparison of the effects of pretreatment intravenous fentanyl or intravenous lidocaine on suppression of fentanyl-induced cough in children: a randomized, double-blind, controlled clinical trial Full Text available with Trip Pro

of low dose of fentanyl with lidocaine in prevention of fentanyl-induced cough in children.This randomized double-blind controlled clinical trial study was conducted at Motahari Hospital between February and August 2017 in Urmia (Iran). One hundred patients, aged 2-10 years, of class I or II ASA status who were candidates for elective herniorrhaphy under general anesthesia were enrolled in this study. They were randomly divided into three groups. One minute before the administration of 2 μg/kg

2018 Electronic physician Controlled trial quality: uncertain

167. Implantation of a permanent leadless and batteryless haemodynamic sensor and associated remote analysis of pulmonary artery pressure for patients with moderate chronic heart failure (New York Heart Association class III)

it was reasonable to assume a single insertion over a patient's lifetime, incremental costs associated with aspirin therapy and complications associated with 4 aspirin therapy, and incremental costs associated with training and monitoring should also be included in the economic analysis. MSAC considered that the estimate of likely patient numbers (48–960) may be conservative. The financial impact to the government, calculated to be $1.3 million in year one increasing to $27.6 million in year five, was therefore

2015 Medical Services Advisory Committee

168. Cardiovascular Disease: Interventions Engaging Community Health Workers

" OR "physical activity" OR "tobacco" OR "nutrition" OR "diet" OR "diets" OR "dieting" OR alcohol* OR "aspirin" OR adher* OR "cardiovascular disease" or "cardiovascular diseases" or "comprehensive CVD risk reduction" OR "comprehensive cardiovascular disease risk reduction" OR "chronic disease" OR "chronic diseases") OR MH "Chronic Disease" OR MH "Patient Compliance+" OR MH "Medication Compliance" OR MH "Aspirin" OR MH "Alcoholic Intoxication" OR MH "Alcoholism" OR MH "Alcohol Rehabilitation Programs+" OR MH (...) Hypertension or blood pressure or cholesterol or diabetes or obesity or physical activity or tobacco or nutrition or diet or alcohol or aspirin or adherence or comprehensive CVD risk reduction or chronic disease or cardiovascular disease or cardiovascular diseases:ti,ab,kw [Word variations have been searched] #3 #1 and #2 #4 Team-based care or integrated care or coordinated care or collaborative care or primary care teams or navigator or liaison or screening or education or outreach or home visits

2015 Community Preventive Services Task Force

169. Colonoscopy Outcomes by Duration of NPO Status Prior to Colonoscopy with Moderate or Deep Sedation

rates, adenoma detection rate, total procedure time, cecal intubation time, withdrawal time, patient adherence, patient satisfaction, or volume of gastric contents. No studies reported false negative colonoscopies, hospitalizations, costs, unused procedure slots, delays in rescheduling, delays in diagnosis, increased volume of procedures, scheduler and nursing time, or acidity of the gastric contents. Detailed outcome data are presented in Appendix C, Tables 2 through 6. Table 1. Summary of Baseline (...) using split-dose regimens for bowel preparation, such that the second dose of laxative is administered 4 to 6 hours before the colonoscopy, with completion at least 2 hours before the exam. Additionally, the ASA guidelines support NPO of 2 hours after clear liquids. 10 However, 35 NPO Status Prior to Colonoscopy Evidence-based Synthesis Program there is a need for larger studies comparing shorter durations of NPO prior to colonoscopy (such as 2 to 4 hours) to longer intervals of NPO prior

2015 Veterans Affairs Evidence-based Synthesis Program Reports

172. Ticagrelor (Brilique) for preventing thombotic events in patients with acute ischaemic stroke or high risk transient ischaemic attack

belongs to a class of drugs called cyclopentyltriazolopyrimidine inhibitors, which bind directly to the P2Y₁₂ receptor without conversion to an active metabolite. This allows a rapid onset of action. Ticagrelor is intended to prevent thrombotic events in patients with acute ischaemic stroke or high risk transient ischaemic attack (TIA). Ticagrelor is administered at a dose of 90mg twice daily, following a single 180mg loading dose. It is currently licensed in combination with aspirin (...) year and is associated with a high risk of stroke in the first month after the event and up to one year afterwards. Current treatment for patients following ischaemic stroke or TIA includes medications such as anticoagulants, antiplatelets, statins and thrombolytic agents. Surgery is also an option for some patients. Ticagrelor is currently in a phase III clinical trial investigating its effects on reducing subsequent vascular events as compared to aspirin. Results from this trial are expected

2015 Health Technology Assessment (HTA) Database.

173. Neostigmine for reversal of neuromuscular block in paediatric patients. (Abstract)

); EMBASE via Ovid SP (1974 to August 2013); ClinicalTrials.gov (18 August 2013) and Chinese Clinical Trial Registry (18 August 2013) with no language restrictions.We planned to include randomized controlled trials (RCTs) comparing neostigmine versus placebo in American Society of Anaesthesiologists (ASA) I or II paediatric surgical participants (younger than 12 years of age, including newborns) who had received non-depolarizing muscle relaxants.Two review authors independently assessed the studies

2014 Cochrane

175. Contrast-induced Nephropathy

bicarbonate versus N-acetylcysteine plus IV saline; 8 RCTs comparing a statin versus IV saline; 5 RCTs comparing a statin plus N-acetylcysteine versus N-acetylcysteine; 6 RCTs comparing statin versus statin, statin by dose, or statins plus other agents; 5 RCTs comparing an adenosine antagonist versus IV saline; 6 RCTs investigating hemodialysis or hemofiltration versus IV saline; 6 RCTs comparing ascorbic acid versus IV saline, and 3 RCTs comparing ascorbic acid to N-acetylcysteine. Although we found many (...) of CIN (RR, 0.93; 95% CI, 0.68 to 1.27). The SOE was low for a clinically important reduction in CIN that was not statistically significant when comparing IV sodium bicarbonate with IV saline in patients receiving LOCM (RR, 0.65; 95% CI, 0.33 to 1.25). The SOE was low for a clinically important reduction in CIN that was not statistically significant when comparing ascorbic acid with IV saline (RR, 0.72; 95% CI, 0.48 to 1.01). The SOE was low that use of hemodialysis versus IV saline to prevent CIN

2016 Effective Health Care Program (AHRQ)

176. Resveratrol has a positive effect on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease. (Abstract)

, aspirin). Resveratrol at a dose of 100 mg per os daily was added to standard treatment of the patients of the research group. The day before randomization and 2 months after the prescribing therapy to the patients, echocardiography (echo) and 24 hour Holter ECG monitoring were made.Diastolic dysfunction of the left ventricle (LV) in the form of violation of relaxation (type I) had been found in 100 % of patients with CHD. The 24 hour Holter ECG monitoring revealed episodes of myocardial ischemia (σt

2017 Wiadomosci lekarskie (Warsaw, Poland : 1960) Controlled trial quality: uncertain

177. Cardiovascular Primary Prevention Choice

Cardiovascular Primary Prevention Choice Cardiovascular Primary Prevention Choice | Mayo Clinic Shared Decision Making National Resource Center Toggle navigation Cardiovascular Primary Prevention Choice Statin/Aspirin Choice Decision Aid The risk reductions attributed to statins and decision aids come from systematic reviews of randomized trials of primary prevention of coronary events with (25-30% reduction in risk of coronary events) and (15-20% reduction in coronary events). The risk (...) reduction in coronary events with fixed standard dose statins (atorvastatin 10 mg, simvastatin 40 mg, pravastatin 40 mg, rosuvastatin 5 mg) has been stable for years and was recently documented in a to be 25%, with high dose statins (2-3 times standard dose) adding about 15% relative risk reduction (i.e., 40% risk reduction). Low-dose aspirin can reduce coronary events by about and can impact the risk and outcomes of colon cancer and other cancers. Tools: Risk calculators: : 10-year Coronary Heart

2016 Washington Health Care Authority

178. Ginkgo biloba extract improved cognitive and neurological functions of acute ischaemic stroke: a randomised controlled trial Full Text available with Trip Pro

assigned to the GBE group (450 mg GBE with 100 mg aspirin daily) or the control group (100 mg aspirin daily) for 6 months. The primary outcome was the decline in the Montreal Cognitive Assessment score at 6 months. Secondary outcomes were other neuropsychological tests of cognitive and neurological function, the the incidence of adverse events and vascular events.348 patients were enrolled: 179 in the GBE group and 169 in the control group. With 18 patients lost to follow-up, the dropout rate was 5.17 (...) , 90 and 180 days in the GBE group were significantly improved compared with controls. Improvements were also observedin GBE groups for Mini-Metal State Examination scores of 30, 90 and 180 days, Webster's digit symbol test scores at 30 days and Executive Dysfunction Index scores at 30 and 180 days. No significant differences were seen in the incidence of adverse events or vascular events.We conclude that GBE in combination with aspirin treatment alleviated cognitive and neurological deficits after

2017 Stroke and vascular neurology Controlled trial quality: predicted high

179. A retrospective analysis on patients at high‐risk for obstructive sleep apnea undergoing ear, nose, and throat surgeries Full Text available with Trip Pro

for data analysis. Patients were divided into two groups based on the number of OSA risk factors: group A with 3-4 risk factors (n = 166), and group B with ≥5 risk factors (n = 126). The following information was collected: demographics, ASA, preoperative STOP-BANG score, length of surgery, intraoperative complications, opioid consumption, post anesthesia care unit (PACU) and overall length of stay, supplemental oxygen requirement, oxygen desaturation, and postoperative opioid consumption.No

2017 Laryngoscope investigative otolaryngology

180. Atypical desquamation in a 2.5-year-old boy with Kawasaki disease: A case report Full Text available with Trip Pro

of KD was proved, oral acetylsalicylic acid with the anti-inflammatory dose and intravenous immunoglobulin were started for him. On the seventh day of admission time, he developed desquamation and erythema on the site of his right cervical lymphadenopathy as well as periungual scaling. About three weeks after starting the treatment, scaling of the cervical lymphadenopathy and periungual area stopped. Echocardiography was performed for him three times: at the time of diagnosis, four weeks, and 6

2017 Electronic physician

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