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161. Review of acute ischaemic stroke in Pakistan: progress in management and future perspectives Full Text available with Trip Pro

in Pakistan. We reviewed the available literature on stroke from Pakistan and through this article we primarily aim to present the current acute ischaemic stroke management in Pakistan in juxtaposition to that of the developed world. We also intend to highlight areas for future development and improvement in management. The routine practice in Pakistan is that of using stat dose of aspirin in emergency (ER) at large with only a handful of centres offering thrombolytic therapy with recombinant tissue

2017 Stroke and vascular neurology

162. Resveratrol has a positive effect on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease. (Abstract)

, aspirin). Resveratrol at a dose of 100 mg per os daily was added to standard treatment of the patients of the research group. The day before randomization and 2 months after the prescribing therapy to the patients, echocardiography (echo) and 24 hour Holter ECG monitoring were made.Diastolic dysfunction of the left ventricle (LV) in the form of violation of relaxation (type I) had been found in 100 % of patients with CHD. The 24 hour Holter ECG monitoring revealed episodes of myocardial ischemia (σt

2017 Wiadomosci lekarskie (Warsaw, Poland : 1960) Controlled trial quality: uncertain

163. The influence of non-steroidal anti-inflammatory drugs and paracetamol used for pain control of orthodontic tooth movement: a systematic review. Full Text available with Trip Pro

, from which 6 studies were eligible after a qualitative analysis. From the drugs assessed, paracetamol was unanimous for not interfering within orthodontic movement when compared to the control group. However, drugs such as aspirin, ibuprofen, sodium diclofenac, and selective cyclooxygenase-2 inhibitors caused a reduction in tooth movement when compared to the control group.paracetamol could be considered the drug of choice for pain relief because it interferes less within tooth movement.

2017 Anais da Academia Brasileira de Ciencias

164. Cardiovascular Primary Prevention Choice

Cardiovascular Primary Prevention Choice Cardiovascular Primary Prevention Choice | Mayo Clinic Shared Decision Making National Resource Center Toggle navigation Cardiovascular Primary Prevention Choice Statin/Aspirin Choice Decision Aid The risk reductions attributed to statins and decision aids come from systematic reviews of randomized trials of primary prevention of coronary events with (25-30% reduction in risk of coronary events) and (15-20% reduction in coronary events). The risk (...) reduction in coronary events with fixed standard dose statins (atorvastatin 10 mg, simvastatin 40 mg, pravastatin 40 mg, rosuvastatin 5 mg) has been stable for years and was recently documented in a to be 25%, with high dose statins (2-3 times standard dose) adding about 15% relative risk reduction (i.e., 40% risk reduction). Low-dose aspirin can reduce coronary events by about and can impact the risk and outcomes of colon cancer and other cancers. Tools: Risk calculators: : 10-year Coronary Heart

2016 Washington Health Care Authority

165. Mortality Following Cardiovascular and Bleeding Events Occurring Beyond 1 Year After Coronary Stenting: A Secondary Analysis of the Dual Antiplatelet Therapy (DAPT) Study. Full Text available with Trip Pro

, a multicenter trial involving 220 US and international clinical sites from 11 countries. The study dates were August 2009 to May 2014. Individuals who underwent coronary stenting and completed 12 months of thienopyridine plus aspirin therapy without ischemic or bleeding events remained on an aspirin regimen and were randomized to continued thienopyridine therapy vs placebo for 18 additional months. Individuals were then followed up for 3 additional months while receiving aspirin therapy alone. The analysis

2017 JAMA cardiology

166. Transcatheter occlusion of the left atrial appendage for patients with non-valvular atrial fibrillation

, and the list of risk factors should be limited to one or more of those listed. In relation to the second point, MSAC agreed with its ESC that allowing other possible risk factors would allow lower risk patients to become eligible, and considered that this would be associated with expected reduced effectiveness and less favourable cost-effectiveness. MSAC expressed reservations over the proposed comparator of oral antiplatelet (OAP) therapy (specifically presented in the application as being aspirin plus (...) clopidogrel). There were two issues noted by MSAC with regard to using this comparator for the assessment. First, the most common contraindication to OAT is increased risk of bleeding. However, OAP therapy is also associated with an increased risk of bleeding as indicated by both the ACTIVE-W randomised trial comparing clopidogrel plus aspirin against vitamin K antagonists such as warfarin (relative risk (RR) = 1.21; 95% CI 1.08 – 1.35, acknowledging that the statistically significant increase in risk

2014 Medical Services Advisory Committee

167. The appropriate use of neuroimaging in the diagnostic work-up of dementia: an economic literature review and cost-effectiveness analysis

dementia were assumed to receive aspirin. Location/setting Canada/secondary care. Methods Analytical approach: A decision tree was developed to determine the positive and negative predictive values of disease. Markov models were then used to determine the costs and utilities of the natural history of dementia with different causes. All models were probabilistic. The causes were Alzheimer's disease, vascular dementia, normal-pressure hydrocephalus, subdural haematoma, and brain tumour. The time horizon (...) dementia models. Measure of benefit: The summary measure of benefit was quality-adjusted life-years (QALYs), which were discounted at a rate of 5% annually. Cost data: The costs included the drugs, imaging, procedures and care for dementia of various causes. The drug costs were from Ontario Drug Benefit data, and included donepezil and aspirin. The imaging costs were from the Ontario Case Costing Initiative. The costs of procedures and care for dementia of each cause were from a variety of published

2014 NHS Economic Evaluation Database.

168. Safety and efficacy of early administration of tirofiban in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a meta-analysis

(catheterization laboratory) administration of tirofiban in patients undergoing primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) were eligible. Studies with follow-up data in less than 90% of patients were excluded. The authors did not state how many reviewers selected the studies. Patient age ranged from 57 to 68 years. Most participants were male. In most studies, patients were preprocedurally treated with aspirin and clopidogrel. Aspirin

2014 DARE.

172. Antiplatelet and anticoagulation for patients with prosthetic heart valves. (Abstract)

information from the trials.One new study has been identified and included in this update. In total, 13 studies involving 4122 participants were included in this review update. Years of publication ranged from 1971 to 2011. Compared with anticoagulation alone, the addition of an antiplatelet agent reduced the risk of thromboembolic events (odds ratio (OR) 0.43, 95% confidence interval (CI) 0.32 to 0.59; P < 0.00001) and total mortality (OR 0.57, 95% CI 0.42 to 0.78; P = 0.0004). Aspirin and dipyridamole (...) reduced these events similarly. The risk of major bleeding was increased when antiplatelet agents were added to oral anticoagulants (OR 1.58, 95% CI 1.14 to 2.18; P = 0.006).For major bleeding, there was no evidence of heterogeneity between aspirin and dipyridamole and in the comparison of trials performed before and after 1990, around the time when anticoagulation standardisation with the international normalised ratio was being implemented. A lower daily dose of aspirin (< 100 mg) may be associated

2013 Cochrane

173. WITHDRAWN: Non-steroidal anti-inflammatory drugs for preventing heterotopic bone formation after hip arthroplasty. (Abstract)

methodological quality and extracted data. All analyses were conducted on dichotomised outcomes.Sixteen randomised and two quasi-randomised trials involving a total of 4,763 patients were included. Overall, in 17 trials that examined the effects of medium to high doses of NSAIDs, there was a reduced risk of developing HBF after hip surgery (59% reduction, 95% confidence interval 54% to 64% reduction). In contrast, one large trial examining low-dose aspirin, demonstrated no effect on the risk of HBF (2 (...) -intestinal complications. Data on the late post-operative outcomes of pain, impaired physical function and range of joint movement were few and no formal overviews of the effects of NSAIDs on these outcomes were possible.Perioperative NSAIDs, apart from low dose aspirin, appear to produce between a one half and two thirds reduction in the risk of HBF. With routine use, such agents may be able to prevent 15-20 cases of HBF among every 100 total hip replacements performed. However, while medium to high

2013 Cochrane

174. Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction. (Abstract)

strategy identified 18 reports of 14 studies for consideration. The original review included five studies (484 women) which met the inclusion criteria, with a further five studies included in the updated review, involving an additional 655 women. The overall quality of the included trials was considered fair to good.Nine studies compared heparin (alone or in combination with dipyridamole or low-dose aspirin) with no treatment; and one compared trapidil (triazolopyrimidine).While this review identified

2013 Cochrane

175. Vitamin K antagonists versus antiplatelet therapy after transient ischaemic attack or minor ischaemic stroke of presumed arterial origin. (Abstract)

Vitamin K antagonists versus antiplatelet therapy after transient ischaemic attack or minor ischaemic stroke of presumed arterial origin. People who have had a transient ischaemic attack (TIA) or non-disabling ischaemic stroke have an annual risk of major vascular events of between 4% and 11%. Aspirin reduces this risk by 20% at most. Secondary prevention trials after myocardial infarction indicate that treatment with vitamin K antagonists is associated with a risk reduction approximately twice

2012 Cochrane

176. Anti-inflammatory treatment for carditis in acute rheumatic fever. (Abstract)

Anti-inflammatory treatment for carditis in acute rheumatic fever. Rheumatic heart disease remains an important cause of acquired heart disease in developing countries. Although the prevention of rheumatic fever and the management of recurrences is well established, the optimal management of active rheumatic carditis is still unclear. This is an update of a review published in 2003 and previously updated in 2009.To assess the effects of anti-inflammatory agents such as aspirin, corticosteroids (...) , immunoglobulin and pentoxifylline for preventing or reducing further heart valve damage in patients with acute rheumatic fever.We searched the Cochrane Central Register of Controlled Trials on The Cochrane Library (Issue 3, 2011), MEDLINE (1966 to Aug 2011), EMBASE (1998 to Sept 2011), LILACS (1982 to Sept 2011), Index Medicus (1950 to April 2001) and references lists of identified studies. No language restrictions were applied.Randomised controlled trials comparing anti-inflammatory agents (e.g. aspirin

2012 Cochrane

177. Anticoagulation versus placebo for heart failure in sinus rhythm. (Abstract)

and benefits from antithrombotic therapy using relative measures of effects, such as odds ratio, accompanied with 95% confidence intervals.Two RCTs were identified. One compared warfarin, aspirin and no antithrombotic therapy and the second compared warfarin with placebo in patients with idiopathic dilated cardiomyopathy. Three small prospective controlled studies of warfarin in heart failure were also identified, but were over 50 years old with methods not considered reliable by modern standards. In both

2012 Cochrane

178. Intervention strategies to reduce the burden of non-communicable diseases in Mexico: cost effectiveness analysis Full Text available with Trip Pro

cancer treatment) to more than INT$ 1 billion (for high coverage of treatment for hypercholesterolaemia or aggressive management of absolute cardiovascular risk). The DALYs averted ranged from less than 1,000 (for some components of cancer treatment or aspirin therapy) to more than 300,000 (for an aggressive combination of interventions to deal with alcohol use and cardiovascular risk). The cost per DALY averted ranged from less than INT$ 100 with taxation for alcohol, to more than INT$ 100,000 (...) with high-intensity treatment for COPD or aspirin for acute ischaemic stroke. The dominated interventions, which were less effective and more expensive than another option, were excluded. For depression, newer antidepressant drugs in primary care, at target coverage, or newer antidepressant drugs plus psychotherapy, at target coverage, were cost-effective.For heavy alcohol use, increased taxation, increased taxation plus advertising bans, or increased taxation plus brief advice plus bans plus reduced

2013 NHS Economic Evaluation Database.

179. Restorative Justice Conferencing (RJC) Using Face?to?Face Meetings of Offenders and Victims: Effects on Offender Recidivism and Victim Satisfaction. A Systematic Review

a challenge in a systematic review that integrates the findings of diverse tests. Examining the effects of RJCs across a wide range of offenses and offender types is not unlike examining the effects of aspirin across a wide range of diseases, including cancer, heart disease, influenza, sunburn, and syphilis. Further, the character of RJ conferences may change in relation to the populations and problems studied. There is no a priori reason to expect any intervention to be equally or consistently effective

2013 Campbell Collaboration

180. Intravenous acetaminophen for acute postoperative pain in adults

the medications acetaminophen, opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), selective inhibitors of cyclo-oxygenase-2, ketamine, aspirin, and nonpharmacologic therapies. Opioids have side effects that can be dose limiting such as nausea, vomiting, constipation, decreased gastrointestinal motility, urinary retention, sedation, confusion, and respiratory depression. NSAIDs are contraindicated in patients with renal impairment and may cause bleeding, platelet dysfunction, renal toxicity

2014 Health Technology Assessment (HTA) Database.

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