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141. Inequality in Care and Differences in Outcome Following Stroke in People With ESRD Full Text available with Trip Pro

patients were less likely to be functionally independent (61.4% vs. 77.7%; P < 0.0001) before stroke, less frequently admitted to stroke units (64.6% vs. 79.6%; P < 0.001), or to receive aspirin (75.3% vs. 83.2%; P = 0.01) than non-ESRD stroke patients. There were no significant differences in management of kidney transplantation patients. Stroke with ESRD was associated with a higher death rate during admission (dialysis 22.9% vs.14.4%, P = 0.002; transplantation: 19.6% vs. 9.3%; P = 0.034). Managing

2018 Kidney international reports

142. Diabetes Prevention: Interventions Engaging Community Health Workers

" OR "diets" OR "dieting" OR alcohol* OR "aspirin" OR adher* OR "cardiovascular disease" or "cardiovascular diseases" or "comprehensive CVD risk reduction" OR "comprehensive cardiovascular disease risk reduction" OR "chronic disease" OR "chronic diseases") OR MH "Chronic Disease" OR MH "Patient Compliance+" OR MH "Medication Compliance" OR MH "Aspirin" OR MH "Alcoholic Intoxication" OR MH "Alcoholism" OR MH "Alcohol Rehabilitation Programs+" OR MH "Ethanol+" OR MH "Alcohol-Induced Disorders, Nervous (...) or physical activity or tobacco or nutrition or diet or alcohol or aspirin or adherence or comprehensive CVD risk reduction or chronic disease or cardiovascular disease or cardiovascular diseases:ti,ab,kw [Word variations have been searched] #3 #1 and #2 #4 Team-based care or integrated care or coordinated care or collaborative care or primary care teams or navigator or liaison or screening or education or outreach or home visits or enroll or community organizer or community development or health advocacy

2016 Community Preventive Services Task Force

143. Implantation of a permanent leadless and batteryless haemodynamic sensor and associated remote analysis of pulmonary artery pressure for patients with moderate chronic heart failure (New York Heart Association class III)

it was reasonable to assume a single insertion over a patient's lifetime, incremental costs associated with aspirin therapy and complications associated with 4 aspirin therapy, and incremental costs associated with training and monitoring should also be included in the economic analysis. MSAC considered that the estimate of likely patient numbers (48–960) may be conservative. The financial impact to the government, calculated to be $1.3 million in year one increasing to $27.6 million in year five, was therefore

2015 Medical Services Advisory Committee

144. Cardiovascular Disease: Interventions Engaging Community Health Workers

" OR "physical activity" OR "tobacco" OR "nutrition" OR "diet" OR "diets" OR "dieting" OR alcohol* OR "aspirin" OR adher* OR "cardiovascular disease" or "cardiovascular diseases" or "comprehensive CVD risk reduction" OR "comprehensive cardiovascular disease risk reduction" OR "chronic disease" OR "chronic diseases") OR MH "Chronic Disease" OR MH "Patient Compliance+" OR MH "Medication Compliance" OR MH "Aspirin" OR MH "Alcoholic Intoxication" OR MH "Alcoholism" OR MH "Alcohol Rehabilitation Programs+" OR MH (...) Hypertension or blood pressure or cholesterol or diabetes or obesity or physical activity or tobacco or nutrition or diet or alcohol or aspirin or adherence or comprehensive CVD risk reduction or chronic disease or cardiovascular disease or cardiovascular diseases:ti,ab,kw [Word variations have been searched] #3 #1 and #2 #4 Team-based care or integrated care or coordinated care or collaborative care or primary care teams or navigator or liaison or screening or education or outreach or home visits

2015 Community Preventive Services Task Force

145. Ticagrelor (Brilique) for preventing thombotic events in patients with acute ischaemic stroke or high risk transient ischaemic attack

belongs to a class of drugs called cyclopentyltriazolopyrimidine inhibitors, which bind directly to the P2Y₁₂ receptor without conversion to an active metabolite. This allows a rapid onset of action. Ticagrelor is intended to prevent thrombotic events in patients with acute ischaemic stroke or high risk transient ischaemic attack (TIA). Ticagrelor is administered at a dose of 90mg twice daily, following a single 180mg loading dose. It is currently licensed in combination with aspirin (...) year and is associated with a high risk of stroke in the first month after the event and up to one year afterwards. Current treatment for patients following ischaemic stroke or TIA includes medications such as anticoagulants, antiplatelets, statins and thrombolytic agents. Surgery is also an option for some patients. Ticagrelor is currently in a phase III clinical trial investigating its effects on reducing subsequent vascular events as compared to aspirin. Results from this trial are expected

2015 Health Technology Assessment (HTA) Database.

146. Heparin versus placebo for non-ST elevation acute coronary syndromes. Full Text available with Trip Pro

Heparin versus placebo for non-ST elevation acute coronary syndromes. Non-ST elevation acute coronary syndromes (NSTEACS) represent a spectrum of disease including unstable angina and non-ST segment myocardial infarction (NSTEMI). Despite treatment with aspirin, beta-blockers and nitroglycerin, unstable angina/NSTEMI is still associated with significant morbidity and mortality. Although evidence suggests that low molecular weight heparin (LMWH) is more efficacious compared to unfractionated

2014 Cochrane

147. Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke. (Abstract)

inhibition with fibrinogen and, due to their mechanism of action, are likely to have a more profound antiplatelet effect with more rapid onset than conventional antiplatelet agents, such as aspirin or clopidogrel. Currently used in clinical practice for the treatment of individuals with acute coronary syndromes and during coronary angioplasty, GP IIb-IIIa inhibitors could also be useful for the treatment of people with acute ischaemic stroke.To assess the use of GP IIb-IIIa inhibitors in people (...) included four trials involving 1365 participants. Three trials compared the intravenous GP IIb-IIIa inhibitor Abciximab with intravenous placebo (1215 participants) and one trial compared the intravenous GP IIb-IIIa inhibitor Tirofiban with intravenous aspirin (150 participants). Treatment with either of these GP IIb-IIIa inhibitors did not significantly reduce long-term death or dependency (odds ratio (OR) 0.97, 95% confidence interval (CI) 0.77 to 1.22, for the comparison between Abciximab

2014 Cochrane

148. Oral antiplatelet therapy for acute ischaemic stroke. Full Text available with Trip Pro

trials, they extracted and cross-checked the data.We included eight trials involving 41,483 participants. No new trials have been added since the last update.Two trials testing aspirin 160 mg to 300 mg once daily, started within 48 hours of onset, contributed 98% of the data. The risk of bias was low. The maximum follow-up was six months. With treatment, there was a significant decrease in death or dependency at the end of follow-up (odds ratio (OR) 0.95, 95% confidence interval (CI) 0.91 to 0.99 (...) ). For every 1000 people treated with aspirin, 13 people would avoid death or dependency (number needed to treat 79). Antiplatelet therapy was associated with a small but definite excess of symptomatic intracranial haemorrhages, but this small hazard was significantly outnumbered by the benefit, the reduction in recurrent ischaemic stroke and pulmonary embolus.Antiplatelet therapy with aspirin 160 mg to 300 mg daily, given orally (or by nasogastric tube or per rectum in people who cannot swallow

2014 Cochrane

149. Anticoagulation versus placebo for heart failure in sinus rhythm. Full Text available with Trip Pro

or a third party.Two review authors independently assessed trials for inclusion and assessed the risks and benefits of antithrombotic therapy using relative measures of effects, such as odds ratio, accompanied by the 95% confidence intervals.Two RCTs were identified. One compared warfarin, aspirin and no antithrombotic therapy and the second compared warfarin with placebo in patients with idiopathic dilated cardiomyopathy. Three small prospective controlled studies of warfarin in heart failure were also

2014 Cochrane

150. Colchicine for pericarditis. Full Text available with Trip Pro

. Secondary outcomes were the rate of recurrences at 6, 12 and 18 months, and symptom relief.We included four RCTs, involving 564 participants in this review. We compared the effects of colchicine in addition to a non-steroidal anti-inflammatory drug (NSAID) such as ibuprofen, aspirin or indomethacin to the effects of the NSAID alone. Two comparable trials studied the effects of colchicine in 204 participants with recurrent pericarditis and two trials studied 360 people with acute pericarditis. All trials

2014 Cochrane

151. Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy. Full Text available with Trip Pro

). In patients with multiple myeloma, LMWH was associated with a significant reduction in symptomatic VTE when compared with the vitamin K antagonist warfarin (RR 0.33, 95% CI 0.14 to 0.83), while the difference between LMWH and aspirin was not statistically significant (RR 0.51, 95% CI 0.22 to 1.17). No major bleeding was observed in the patients treated with LMWH or warfarin and in less than 1% of those treated with aspirin. Only one study evaluated unfractionated heparin against inactive control and found

2014 Cochrane

153. Paradoxical embolism: Experiences from a single center Full Text available with Trip Pro

resuscitation. Eleven patients were discharged with improvements. No late mortality occurred in 8 patients with a complete follow-up of 10.6-17.7 years. One had a recurrent deep venous thrombosis. No patient had a recurrent pulmonary or arterial embolism. Two patients changed their treatment from warfarin to aspirin; others remained on warfarin. Only 1 case had an occasional gum bleeding.PDE treatment including thrombolysis, anticoagulation, and embolectomy should be individualized. We recommend long-term

2017 Chronic diseases and translational medicine

154. Ginkgo biloba extract improved cognitive and neurological functions of acute ischaemic stroke: a randomised controlled trial Full Text available with Trip Pro

assigned to the GBE group (450 mg GBE with 100 mg aspirin daily) or the control group (100 mg aspirin daily) for 6 months. The primary outcome was the decline in the Montreal Cognitive Assessment score at 6 months. Secondary outcomes were other neuropsychological tests of cognitive and neurological function, the the incidence of adverse events and vascular events.348 patients were enrolled: 179 in the GBE group and 169 in the control group. With 18 patients lost to follow-up, the dropout rate was 5.17 (...) , 90 and 180 days in the GBE group were significantly improved compared with controls. Improvements were also observedin GBE groups for Mini-Metal State Examination scores of 30, 90 and 180 days, Webster's digit symbol test scores at 30 days and Executive Dysfunction Index scores at 30 and 180 days. No significant differences were seen in the incidence of adverse events or vascular events.We conclude that GBE in combination with aspirin treatment alleviated cognitive and neurological deficits after

2017 Stroke and vascular neurology Controlled trial quality: predicted high

155. Antiphosphospholipid syndrome presenting with amaurosis fugax and cotton wool spots Full Text available with Trip Pro

on positive serologic testing for antiphosphatidylserine IgM, anticardiolipin IgM. The patient was treated with lipid lowering medication, long-term aspirin, and has followed a weightloss and physical therapy program under medical supervision. The CWS resolved and AF symptoms have not recurred.Antiphospholipid syndrome can be considered in the differential diagnosis of patients presenting with AF, assymetric CWS, and/or rapid progression of symptoms.

2017 American journal of ophthalmology case reports

156. Risk factors associated with 90-day recurrent stroke in patients on dual antiplatelet therapy for minor stroke or high-risk TIA: a subgroup analysis of the CHANCE trial Full Text available with Trip Pro

attack or minor stroke receiving clopidogrel and aspirin in the trial were analysed in the study. The primary outcome was recurrent stroke within 90 days after the index event. Cox proportional hazard model with backward selection was used to identify factors associated with stroke.Among 2584 patients, 212 (8.2%) had a recurrent stroke, 216 (8.4%) had a composite of stroke, myocardial infarction, or vascular death and 204 (7.9%) had ischaemic stroke within 90 days. Multivariate analysis identified (...) the following factors associated with stroke: history of hypertension with poor blood pressure control (HR, 1.92; 95% CI 1.22 to 3.03), the high baseline National Institute of Health Stroke Scale (NIHSS) score of 2 and 3 (2.12 (1.07 to 4.21) and 4.11 (2.05 to 8.22), respectively), time from onset to randomisation of <12 hours (1.47 (1.12 to 1.94)), the lipid-lowering therapy (0.61 (0.47 to 0.83)), the open-label aspirin dose at day 1 of ≥300 mg (1.98 (1.45 to 2.69)). Intracranial arterial stenosis (ICAS

2017 Stroke and vascular neurology

157. Does the Drug Facts Label for nonprescription drugs meet its design objectives? A new procedure for assessing label effectiveness Full Text available with Trip Pro

for aspirin, a Cohesive-Prose Label, or a Scrambled-Prose Label. The Drug Facts Label outperformed the Scrambled-Prose Label, but not the Cohesive-Prose Label, in scanning effectiveness. The Drug Facts Label was no better than the Cohesive-Prose Label or the Scrambled-Prose Label in promoting attentiveness, recall and organization of drug facts, or misconception refutation. Discussion focuses on the need for refutational labels based on a sequence-of-events text schema.

2017 Health psychology open

158. Cumulative incidence, risk factors, and management of atrial fibrillation in patients receiving ibrutinib Full Text available with Trip Pro

to be significant risk factors for development of AF. Most patients were treated with rate control-only strategies (61.8%), and concomitant aspirin or anticoagulant therapy with ibrutinib was used in 52.6% and 28.9% of patients, respectively. One patient on aspirin developed symptoms consistent with stroke. Nine major bleeds were noted in 7 patients, and 34 clinically relevant nonmajor bleeds were noted in 24 patients. Twenty-one bleeds (4 major bleeds) occurred in 18 patients on aspirin, and 10 bleeds (all

2017 Blood advances

159. Under what conditions can a nonprescription drug label serve as refutation text? The role of directed attention and processing strategy Full Text available with Trip Pro

Under what conditions can a nonprescription drug label serve as refutation text? The role of directed attention and processing strategy Nonprescription drug labels are relatively ineffective in refuting drug misconceptions. We sought to improve the effectiveness of an aspirin label as a refutation text by manipulating selective attention and label-processing strategy. After reading a facsimile label, those of 196 undergraduates who attempted to explain why shaded drug facts are "easily confused

2017 Health psychology open

160. Management of anticoagulation in hip fractures: A pragmatic approach Full Text available with Trip Pro

intravenously to correct coagulopathy.The role of fresh frozen plasma is not clear from the current evidence while prothrombin complex remains a reliable and safe method for immediate reversal of VKA-induced coagulopathy in hip fracture surgery or failed vitamin K treatment reversal.The literature suggests that surgery should not be delayed in patients on classical antiplatelet medications (aspirin or clopidogrel), but spinal or regional anaesthetic methods should be avoided for the latter. However

2017 EFORT open reviews

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