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1. Acetylsalicylic acid (aspirin) for schizophrenia. (Abstract)

Acetylsalicylic acid (aspirin) for schizophrenia. Schizophrenia is a serious chronic mental illness affecting an estimated 21 million people worldwide and there is increasing evidence linking inflammation in the brain to the pathophysiology of schizophrenia. Antipsychotic drugs are the conventional treatment for people with schizophrenia but are not always fully effective. Acetylsalicylic acid (aspirin) is a non-steroidal anti-inflammatory drug (NSAID) with properties that inhibit (...) the proinflammatory status of the brain. Using aspirin as an adjunct (add-on) treatment to antipsychotics or as a stand-alone treatment could be a novel, relatively inexpensive option for people with schizophrenia.To review the effects of acetylsalicylic acid (aspirin) as adjunct (add-on) or as stand-alone treatment for people with schizophrenia.We searched the Cochrane Schizophrenia Group's Trials Register (last search 8 March 2018) which is based on regular searches of MEDLINE, Embase, PubMed, CINAHL, BIOSIS

2019 Cochrane

2. Combined Argon Laser and Low Dose Acetylsalicylic acid in Treatment of Acute Central Serous Chorioretinopathy. (Abstract)

Combined Argon Laser and Low Dose Acetylsalicylic acid in Treatment of Acute Central Serous Chorioretinopathy. This study was designed to evaluate the efficacy of low-dose of oral acetylsalicylic acid (aspirin) with focal argon laser for the treatment of acute central serous chorioretinopathy (CSCR). In this prospective case-control study, 40 Patients with acute CSCR were classified randomly to two groups; group A with no treatment as the control group and group B with argon Laser in focal (...) treatment once, followed by aspirin, 100 mg per day orally, with follow up period of 12 months by evaluation of visual acuity, and by Optical Coherence Tomography (OCT), every three months for one year. Patients in the second group treated with argon Laser and aspirin showed more clinically significant improvement in both visual acuity and OCT macular thickness by the end of the follow-up period when compared with the observational group. It was concluded that argon Laser with low-dose oral aspirin

2018 Medical hypothesis, discovery & innovation ophthalmology journal Controlled trial quality: uncertain

3. Acetylsalicylic acid for venous thromboembolism prophylaxis: an update of clinical evidence

. Acetylsalicylic acid for venous thromboembolism prophylaxis: an update of clinical evidence. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response. 2014 Authors' conclusions Two systematic reviews, two randomized controlled trials, and two non-randomized studies were identified regarding the use of acetylsalicylic acid (ASA) for venous thromboembolism (VTE) prophylaxis in patients undergoing total hip or total knee replacement. Final publication URL Indexing Status Subject (...) Acetylsalicylic acid for venous thromboembolism prophylaxis: an update of clinical evidence Acetylsalicylic acid for venous thromboembolism prophylaxis: an update of clinical evidence Acetylsalicylic acid for venous thromboembolism prophylaxis: an update of clinical evidence CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH

2014 Health Technology Assessment (HTA) Database.

4. Codeine and acetylsalicylic acid for the management of post-tonsillectomy or adenoidectomy pain: a review of the clinical evidence

Codeine and acetylsalicylic acid for the management of post-tonsillectomy or adenoidectomy pain: a review of the clinical evidence Codeine and acetylsalicylic acid for the management of post-tonsillectomy or adenoidectomy pain: a review of the clinical evidence Codeine and acetylsalicylic acid for the management of post-tonsillectomy or adenoidectomy pain: a review of the clinical evidence CADTH Record Status This is a bibliographic record of a published health technology assessment from (...) a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Codeine and acetylsalicylic acid for the management of post-tonsillectomy or adenoidectomy pain: a review of the clinical evidence. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response - Summary with Critical Appraisal. 2013 Authors' conclusions No relevant literature was identified regarding the risk of bleeding associated with the use of codeine

2014 Health Technology Assessment (HTA) Database.

5. Should acetylsalicylic acid (ASA) therapy for prevention of thromboembolic events be stopped prior to surgical extractions? Full Text available with Trip Pro

Should acetylsalicylic acid (ASA) therapy for prevention of thromboembolic events be stopped prior to surgical extractions? Randomised controlled trial.Patients with coronary artery disease who were receiving 100 mg/day of ASA for the prevention of thromboembolic events, and requiring at least one molar tooth extracted were randomised to either having their ASA therapy suspended for seven days before tooth extraction and restarted the day following the surgical procedure or not having their ASA (...) therapy suspended at any point before or after the procedure. A single dentist who was unaware of the patients' ASA therapy status performed all the extractions.Outcomes were a platelet aggregation test carried out on the day of the operation and the amount of bleeding measured during the intra-operative period.Bleeding was controlled with local haemostatic methods and there were no reported episodes of haemorrhaging during the intra- and post-operative periods. The mean (±SD) volume of bleeding

2013 Evidence-based dentistry Controlled trial quality: uncertain

6. Low doses of acetylsalicylic acid increase risk of gastrointestinal bleeding in a meta-analysis

Low doses of acetylsalicylic acid increase risk of gastrointestinal bleeding in a meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

7. Fluorouracil/salicylic acid (Actikerall®)

Fluorouracil/salicylic acid (Actikerall®) Fluorouracil/salicylic acid (Actikerall®) Fluorouracil/salicylic acid (Actikerall®) All Wales Medicines Strategy Group (AWMSG) Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation All Wales Medicines Strategy Group (AWMSG). Fluorouracil/salicylic acid (Actikerall®) Penarth: All Wales Therapeutics and Toxicology Centre (AWTTC (...) ), secretariat of the All Wales Medicines Strategy Group (AWMSG). AWMSG Secretariat Assessment Report Advice No.1012. 2012 Authors' conclusions Fluorouracil/salicylic acid (Actikerall®) is recommended as an option for use within NHS Wales for the topical treatment of slightly palpable and/or moderately thick hyperkeratotic actinic keratosis (grade I/II) in immunocompetent adult patients. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Drug Combinations; Fluorouracil; Keratosis

2012 Health Technology Assessment (HTA) Database.

8. Acetylsalicylic acid for venous thromboembolism prophylaxis: a review of clinical evidence, benefits and harms

. No evaluation of the quality of this assessment has been made for the HTA database. Citation Canadian Agency for Drugs and Technologies in Health. Acetylsalicylic acid for venous thromboembolism prophylaxis: a review of clinical evidence, benefits and harms. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). 2011 Authors' conclusions Most of the available evidence from two studies suggested that ASA results in fewer surgical site bleeds and is as effective as vitamin K agonists, low (...) molecular weight heparin, or pentasaccharides for preventing venous thromboembolism after total hip arthroplasty, total knee arthroplasty, and hip fracture surgery. A prospective cohort study suggested that acetylsalicylic acid is less efficacious than low molecular weight heparin in reducing the risk of venous thromboembolism in standard-risk patients Project page URL Indexing Status Subject indexing assigned by CRD MeSH Aspirins; Primary Prevention; Venous Thromboembolism Language Published English

2011 Health Technology Assessment (HTA) Database.

9. Physiological targets of salicylic acid on Artemisia aucheri BOISS as a medicinal and aromatic plant grown under in vitro drought stress Full Text available with Trip Pro

Physiological targets of salicylic acid on Artemisia aucheri BOISS as a medicinal and aromatic plant grown under in vitro drought stress Artemisia aucheri BOISS is a medicinal and aromatic plant, which is endemic to mountainous areas of Iran and surroundings. In this study, we investigated the alleviating effects of salicylic acid (SA) pretreatment (0.01 and 0.1 mM) on A. aucheri under in vitro drought stress induced by 2 and 4% polyethylene glycol (PEG/6000).Plants exposed to PEG stress showed (...) higher levels of H2O2, MDA and electrolyte leakage compared with control. While SA pretreatment decreased these parameters under PEG stress significantly. The activity of CAT, POD, APX, SOD and GR positively changed with PEG and more induction in activity of antioxidant enzymes was observed in SA-pretreated plants under PEG stress. Furthermore, ASA, GSH and their redox ratios (ASC/DHA and GSH/GSSG) enhanced with SA pretreatments. Analysis of our data revealed that MDA, DHA and H2O2 were the best

2016 Botanical studies

10. Mesalamine (5-ASA) for the prevention of recurrent diverticulitis. Full Text available with Trip Pro

Mesalamine (5-ASA) for the prevention of recurrent diverticulitis. Diverticular disease is a common condition that increases in prevalence with age. Recent theories on the pathogenesis of diverticular inflammation have implicated chronic inflammation similar to that seen in ulcerative colitis. Mesalamine, or 5-aminosalicylic acid (5-ASA), is a mainstay of therapy for individuals with ulcerative colitis. Accordingly, 5-ASA has been studied for prevention of recurrent diverticulitis.To evaluate (...) the efficacy of mesalamine (5-ASA) for prevention of recurrent diverticulitis.We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2017, Issue 8), in the Cochrane Library; Ovid MEDLINE (from 1950 to 9 September 2017); Ovid Embase (from 1974 to 9 September 2017); and two clinical trials registries for ongoing trials - Clinicaltrials.gov and the World Health Organization (WHO) International Clinical Trials Registry Platform database (9 September 2017).We also searched proceedings from

2017 Cochrane

11. Acetylsalicylic acid for the prevention of preeclampsia and intra-uterine growth restriction in women with abnormal uterine artery Doppler: a systematic review and meta-analysis

' gestation. Authors' objectives To assess the influence of gestational age at the time of introduction of low-dose acetylsalicylic acid (ASA) on the incidence of pre-eclampsia and intrauterine growth restriction (IUGR) in women at increased risk on the basis of abnormal uterine artery Doppler. Searching MEDLINE, EMBASE and The Cochrane Library were searched without language restrictions from 1965 to 2008. Search terms were reported. Bibliographies of recent two meta-analyses were handsearched (...) Research at the Faculty of Medicine, Université Laval, Québec. Bibliographic details Bujold E, Morency AM, Roberge S, Lacasse Y, Forest JC, Giguere Y. Acetylsalicylic acid for the prevention of preeclampsia and intra-uterine growth restriction in women with abnormal uterine artery Doppler: a systematic review and meta-analysis. Journal of Obstetrics and Gynaecology Canada 2009; 31(9): 818-826 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Aspirin /therapeutic use; Female; Fetal Growth

2009 DARE.

12. Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events. Full Text available with Trip Pro

Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events. Aspirin is the prophylactic antiplatelet drug of choice for people with cardiovascular disease. Adding a second antiplatelet drug to aspirin may produce additional benefit for people at high risk and people with established cardiovascular disease. This is an update to a previously published review from 2011.To review the benefit and harm of adding clopidogrel to aspirin therapy for preventing cardiovascular (...) trials comparing over 30 days use of aspirin plus clopidogrel with aspirin plus placebo or aspirin alone in people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease, or at high risk of atherothrombotic disease. We excluded studies including only people with coronary drug-eluting stent (DES) or non-DES, or both.We collected data on mortality from cardiovascular causes, all-cause mortality, fatal and non-fatal myocardial infarction, fatal and non-fatal ischaemic

2017 Cochrane

13. Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne

Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

16. Arthroscopic bone graft procedure combined with arthroscopic subscapularis augmentation (ASA) for recurrent anterior instability with glenoid bone defect: a cadaver study Full Text available with Trip Pro

Arthroscopic bone graft procedure combined with arthroscopic subscapularis augmentation (ASA) for recurrent anterior instability with glenoid bone defect: a cadaver study Glenoid bone loss and capsular deficiency represent critical points of arthroscopic Bankart repair failures. The purpose of this study was to evaluate an all-arthroscopic bone block procedure associated with arthroscopic subscapularis augmentation (ASA) for treating gleno-humeral instability with glenoid bone loss (GBL (...) . No lesions of the surrounding neurovascular structures were observed. No interference was found between the two bone block tunnels and the anchor tunnel used for the tenodesis.This study demonstrated the feasibility and reproducibility of this combined arthroscopic technique (bone block associated with ASA) in the treatment of anterior shoulder instability associated with anterior bone loss and anterior capsular deficiency.

2018 Journal of experimental orthopaedics

18. Aspirin (single dose) for perineal pain in the early postpartum period. Full Text available with Trip Pro

with newborn care and the establishment of breastfeeding. Aspirin has been used in the management of postpartum perineal pain and its effectiveness and safety should be assessed.To determine the efficacy of a single dose of aspirin (acetylsalicylic acid), including at different doses, in the relief of acute postpartum perineal pain.We searched Cochrane Pregnancy and Childbirth's Trials Register (30 August 2016), ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP) (31 May (...) Aspirin (single dose) for perineal pain in the early postpartum period. Perineal trauma (due to spontaneous tears, surgical incision (episiotomy) or in association with operative vaginal birth) is common after vaginal birth, and is often associated with postpartum perineal pain. Birth over an intact perineum may also lead to perineal pain. There are adverse health consequences associated with perineal pain for the women and their babies in the short- and long-term, and the pain may interfere

2017 Cochrane

19. Salicylate-containing rubefacients for acute and chronic musculoskeletal pain in adults. Full Text available with Trip Pro

Salicylate-containing rubefacients for acute and chronic musculoskeletal pain in adults. Rubefacients containing salicylates cause irritation of the skin and are believed to relieve various musculoskeletal pains. They are available on prescription, and are common components in over-the-counter remedies. This is an update of a review of rubefacients for acute and chronic pain, originally published in 2009, which found limited evidence for efficacy.To assess the efficacy and safety of topically (...) applied salicylates in acute and chronic musculoskeletal pain in adults.We searched CENTRAL, MEDLINE, and EMBASE, from inception to 22 August 2014, together with the Oxford Pain Relief Database, two clinical trial registries, and the reference lists of included studies and relevant reviews.Randomised, double-blind, placebo- or active-controlled clinical trials of topical rubefacients containing salicylates to treat musculoskeletal pain in adults, with at least 10 participants per treatment arm

2014 Cochrane

20. High mucosal healing rates in 5-ASA-treated ulcerative colitis patients: results of a meta-analysis of clinical trials

High mucosal healing rates in 5-ASA-treated ulcerative colitis patients: results of a meta-analysis of clinical trials High mucosal healing rates in 5-ASA-treated ulcerative colitis patients: results of a meta-analysis of clinical trials High mucosal healing rates in 5-ASA-treated ulcerative colitis patients: results of a meta-analysis of clinical trials Romkens TE, Kampschreur MT, Drenth JP, van Oijen MG, de Jong DJ CRD summary The review concluded that 5-aminosalicylate preparations achieved (...) (CENTRAL) were searched. Searched dates were not reported. Search terms were listed. Only full-text publications in English were considered for inclusion. Study selection Randomised controlled trials that reported on mucosal healing after 5-aminosalicylate (5-ASA) monotherapy preparations used to treat patients with mild to moderate ulcerative colitis were included. Mucosal healing was defined in 19 different ways across the studies. Included patients were of an average 40 to 42 years and more than

2012 DARE.

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