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3. RASILEZ (aliskiren), RASILEZ HCT (aliskiren/hydrochlorothiazide), renin inhibitor, alone or in combination with a diuretic

RASILEZ (aliskiren), RASILEZ HCT (aliskiren/hydrochlorothiazide), renin inhibitor, alone or in combination with a diuretic Haute Autorité de Santé - RASILEZ (aliskiren), RASILEZ HCT (aliskiren/hydrochlorothiazide), inhibiteur de la rénine, en association ou non à un diurétique Développer la qualité dans le champ sanitaire, social et médico-social Recherche Évaluation & Recommandation La HAS Accréditation & Certification Outils, Guides & Méthodes Agenda Avis sur les Médicaments RASILEZ

2017 Haute Autorite de sante

4. Heart failure - chronic: Managing diuretics

Heart failure - chronic: Managing diuretics Managing diuretics | Prescribing information | Heart failure - chronic | CKS | NICE Search CKS… Menu Managing diuretics Heart failure - chronic: Managing diuretics Last revised in January 2017 Managing diuretics Choice of diuretic Loop diuretics are preferred for the management of oedema due to heart failure. The loop diuretics available in the UK are furosemide (most widely used), bumetanide, and torasemide. [ ; ] Key drug interactions with loop (...) diuretics Important drug interactions of loop diuretics include: Antibiotics — increased risk of ototoxicity with aminoglycosides, or vancomycin. Only use concurrently if compelling reasons. Increased nephrotoxicity with aminoglycosides or cefaloridine. Increased risk of hyponatraemia with trimethoprim. Impaired renal function may develop with high doses of certain cephalosporins. Antidepressants — enhanced hypotensive effect with monoamine oxidase inhibitors (MAOIs). Increased risk of postural

2020 NICE Clinical Knowledge Summaries

5. Diuretic dosing in heart failure: more data are needed Full Text available with Trip Pro

Diuretic dosing in heart failure: more data are needed 29575802 2018 11 14 2018 11 14 2055-5822 5 4 2018 08 ESC heart failure ESC Heart Fail Diuretic dosing in heart failure: more data are needed. 649-650 10.1002/ehf2.12229 De Vecchis Renato R Cardiology Unit, Presidio Sanitario Intermedio "Elena d'Aosta", via Cagnazzi 29, c.a.p, 80137, Napoli, Italy. Rigopoulos Angelos A Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle (...) England ESC Heart Fail 101669191 2055-5822 0 Diuretics 7LXU5N7ZO5 Furosemide IM ESC Heart Fail. 2018 Feb;5(1):87-94 28967699 Diuretics Furosemide Heart Failure Humans 2017 08 10 2017 09 25 2018 3 27 6 0 2018 11 15 6 0 2018 3 26 6 0 ppublish 29575802 10.1002/ehf2.12229 PMC6073013 ESC Heart Fail. 2018 Feb;5(1):87-94 28967699 Clin Drug Investig. 2017 Apr;37(4):327-342 27766511 ESC Heart Fail. 2018 Mar 25;:null 29575802 Am J Med. 2016 Dec;129(12):1299-1306 27542612 J Card Fail. 2010 Dec;16(12):922-30

2018 ESC heart failure

6. Diuretics Contribute to Reduced Denture Retention

Diuretics Contribute to Reduced Denture Retention UTCAT3066, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Diuretics Contribute to Reduced Denture Retention Clinical Question Do patients taking diuretics experience lost denture retention more than patients not taking diuretics? Clinical Bottom Line Patients who take diuretics as part of medical therapy can experience loss of retention of their denture (...) . This is supported by a non-randomized crossover trial in which denture retention was improved with removal of diuretics. It is not uncommon for denture wearers to be taking diuretics, particularly for hypertension, which is commonly seen in elderly populations. While it may not be advisable to have the patient modify their prescription drug therapy, an awareness of this relationship can guide dentists to compensate for lost retention or to modify denture treatment. Best Evidence (you may view more info

2016 UTHSCSA Dental School CAT Library

7. Rationale and study design of intravenous loop diuretic administration in acute heart failure: DIUR‐AHF Full Text available with Trip Pro

Rationale and study design of intravenous loop diuretic administration in acute heart failure: DIUR‐AHF Although loop diuretics are the most commonly used drugs in acute heart failure (AHF) treatment, their short-term and long-term effects are relatively unknown. The significance of worsening renal function occurrence during intravenous treatment is not clear enough. This trial aims to clarify all these features and contemplate whether continuous infusion is better than an intermittent (...) strategy in terms of decongestion efficacy, diuretic efficiency, renal function, and long-term prognosis.This is a prospective, multicentre, randomized study that compares continuous infusion to intermittent infusion and a low vs. high diuretic dose of furosemide in patients with a diagnosis of acute heart failure, BNP ≥ 100 pg/mL, and specific chest X-ray signs. Randomization criteria have been established at a 1:1 ratio using a computer-generated scheme of either twice-daily bolus injection

2017 ESC heart failure Controlled trial quality: uncertain

8. The association between high‐dose loop diuretic use at discharge and cardiovascular mortality in patients with heart failure Full Text available with Trip Pro

The association between high‐dose loop diuretic use at discharge and cardiovascular mortality in patients with heart failure Few studies have reported the impact of high-dose loop diuretics at discharge on prognosis in Japanese patients with heart failure (HF). Our purpose was to assess the relationship between the dose of loop diuretics at discharge and cardiovascular mortality in patients with HF.We enrolled decompensated HF patients who were admitted to our hospital between March 2010 (...) and March 2015, and compared HF patients who received high-dose loop diuretics at discharge (HD group) with low-dose loop diuretics at discharge (LD group) with regard to risk of cardiovascular mortality, and all-cause mortality. High-dose loop diuretic was defined as ≥40 mg/day of oral furosemide at discharge. A total of 215 patients were enrolled to the study. The median follow-up duration was 641 days. All-cause and cardiovascular mortality were significantly lower in the LD group than in the HD

2017 ESC heart failure

9. Impact of chronic kidney disease on the diuretic response of tolvaptan in acute decompensated heart failure Full Text available with Trip Pro

Impact of chronic kidney disease on the diuretic response of tolvaptan in acute decompensated heart failure This study investigated the relationship between the initial diuretic response to tolvaptan and clinical predictors for tolvaptan responders in patients with acute decompensated heart failure (ADHF).Patients (153) with ADHF (clinical scenario 2 or 3 with signs of fluid retention) who were administered tolvaptan were enrolled. Tolvaptan (15 or 7.5 mg) was administered for at least 7 days (...) to those patients in whom fluid retention was observed even after standard treatment. The maximum urine volume immediately after tolvaptan administration showed good correlations with the ejection fraction and estimated glomerular filtration rate that were independent predictors of the urine volume (UV) responders (≥1500 mL increase in urine volume). The diuretic response (in terms of maximum diuresis) diminished with advancing chronic kidney disease (CKD) stage and concomitant deterioration

2017 ESC heart failure

10. Essentiel hypertension: in 2014, a thiazide diuretic is the first choice

Essentiel hypertension: in 2014, a thiazide diuretic is the first choice Prescrire IN ENGLISH - Spotlight ''Essentiel hypertension: in 2014, a thiazide diuretic is the first choice'', 1 September 2014 {1} {1} {1} | | > > > Essentiel hypertension: in 2014, a thiazide diuretic is the first choice Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight (...) Essentiel hypertension: in 2014, a thiazide diuretic is the first choice In 2014, the first-choice treatment for arterial hypertension in non-diabetic patients with no cardiovascular or kidney involvement, is still a thiazide diuretic. Patients suffering from arterial hypertension are generally asymptomatic but they are exposed to an increased risk of a cardiovascular event. The aim of an antihypertensive treatment is to reduce this risk and to reduce mortality. Pregnancy aside, for non-diabetic

2014 Prescrire

11. Fluids and diuretics for acute ureteric colic. (Abstract)

Fluids and diuretics for acute ureteric colic. Acute ureteric colic is commonly associated with severe and debilitating pain. Theoretically, increasing fluid flow through the affected kidney might expedite stone passage, thereby improving symptoms more quickly. The efficacy and safety of interventions such as high volume intravenous (IV) or oral fluids and diuretics aimed at expediting ureteric stone passage is, however, uncertain.To look at the benefits and harms of diuretics and high volume (...) meetings.All randomised controlled trials (RCTs) and quasi-RCTs (including the first period of randomised cross-over studies) looking at diuretics or high volume IV or oral fluids for treating uncomplicated acute ureteric colic in adult patients presenting to the emergency department for the first time during that episode were included.Two authors independently assessed study quality and extracted data. Statistical analyses were performed using the random-effects model for multiple studies of the same

2012 Cochrane

12. Hypertension - not diabetic: Thiazide-type diuretics

Hypertension - not diabetic: Thiazide-type diuretics Thiazide-type diuretics | Prescribing information | Hypertension - not diabetic | CKS | NICE Search CKS… Menu Thiazide-type diuretics Hypertension - not diabetic: Thiazide-type diuretics Last revised in July 2020 Thiazide-type diuretics Which thiazide-type diuretic should I use? The choice of thiazide-type diuretic usually depends on the person's co-morbidities, local recommendations, and cost. Where possible, prescribe a drug that is taken (...) only once a day and prescribe non-proprietary drugs where these are appropriate and minimise cost. If a person is already taking a conventional thiazide diuretic such as bendroflumethiazide, and their blood pressure is well controlled, continue this treatment. If a thiazide-type diuretic is to be started or changed, indapamide or chlortalidone may be preferred over bendroflumethiazide. [ ; ] Contraindications and cautions Thiazide-type diuretics should be avoided in: People with: Refractory

2017 NICE Clinical Knowledge Summaries

13. Serelaxin for acute decompensated heart failure ? in addition to IV diuretics

Serelaxin for acute decompensated heart failure ? in addition to IV diuretics Serelaxin for acute decompensated heart failure – in addition to IV diuretics Serelaxin for acute decompensated heart failure – in addition to IV diuretics NIHR HSC Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSC. Serelaxin for acute decompensated heart (...) failure – in addition to IV diuretics. Birmingham: NIHR Horizon Scanning Centre (NIHR HSC). Horizon Scanning Review. 2012 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Diuretics; Heart Failure; Humans; Relaxin Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence The NIHR Horizon Scanning Centre, Department of Public Health, Epidemiology, and Biostatistics, School of Health

2012 Health Technology Assessment (HTA) Database.

14. Cohort study: Use of diuretics with ACE inhibitors or angiotensin receptor blockers and NSAIDs increases the risk of acute kidney injury

Cohort study: Use of diuretics with ACE inhibitors or angiotensin receptor blockers and NSAIDs increases the risk of acute kidney injury Use of diuretics with ACE inhibitors or angiotensin receptor blockers and NSAIDs increases the risk of acute kidney injury | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our (...) . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Use of diuretics with ACE inhibitors or angiotensin receptor blockers and NSAIDs increases the risk of acute kidney injury Article

2013 Evidence-Based Medicine

15. Mannitol and other osmotic diuretics as adjuncts for treating cerebral malaria. Full Text available with Trip Pro

Mannitol and other osmotic diuretics as adjuncts for treating cerebral malaria. Cerebral oedema occurs with cerebral malaria, and some clinicians think osmotic diuretics, such as mannitol or urea, may improve outcomes.To compare mannitol or urea to placebo or no diuretic for treating children or adults with cerebral malaria.We searched the Cochrane Infectious Diseases Group Specialized Register (Issue 4, 2010), CENTRAL (The Cochrane Library Issue 12, 2010), MEDLINE (1966 to November 2010 (...) independently.One trial met the inclusion criteria, comparing mannitol 20% to saline placebo in 156 Ugandan children. Allocation was concealed. No difference in mortality, time to regain consciousness, or neurological sequelae were detected.There are insufficient data to know what the effects of osmotic diuretics are in children with cerebral malaria. Larger, multicentre trials are needed.

2011 Cochrane

16. Case control: The use of diuretics plus calcium channel blockers for hypertension may be associated with a higher risk of myocardial infarction but not stroke compared with the combination of diuretics plus ? blockers Full Text available with Trip Pro

Case control: The use of diuretics plus calcium channel blockers for hypertension may be associated with a higher risk of myocardial infarction but not stroke compared with the combination of diuretics plus ? blockers The use of diuretics plus calcium channel blockers for hypertension may be associated with a higher risk of myocardial infarction but not stroke compared with the combination of diuretics plus β blockers | BMJ Evidence-Based Medicine We use cookies to improve our service (...) name or password? You are here The use of diuretics plus calcium channel blockers for hypertension may be associated with a higher risk of myocardial infarction but not stroke compared with the combination of diuretics plus β blockers Article Text Treatment Case control The use of diuretics plus calcium channel blockers for hypertension may be associated with a higher risk of myocardial infarction but not stroke compared with the combination of diuretics plus β blockers Rhonda M Cooper-DeHoff

2010 Evidence-Based Medicine

17. Guidelines for standard and diuretic renogram in children

Guidelines for standard and diuretic renogram in children GUIDELINES Guidelines for standard and diuretic renogram in children Isky Gordon &Amy Piepsz &Rune Sixt # EANM 2011 Abstract Special consideration needs to be given to children who undergo dynamic renography. The Paediatric Committee of the European Association of Nuclear Med- icine has updated the previous guidelines. Details are provided on how to manage the child, the equipment, and the acquisition and processing protocols (...) . The pitfalls, difficulties and controversies that are encountered are also discussed, as well as the interpretation of the results. Keywords Children . Renography . Diuretic . Obstruction Disclaimer This guideline summarises the views of the Paediatric Committee of the European Association of Nuclear Med- icine (EANM) and reflects recommendations for which the EANM cannot be held responsible. These recommenda- tions should be taken in the context of “good practice” of nuclear medicine and do not substitute

2011 European Association of Nuclear Medicine

18. Diuretics have a modest blood pressure lowering effect as second-line therapy for hypertension

Diuretics have a modest blood pressure lowering effect as second-line therapy for hypertension PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Diuretics have a modest blood pressure lowering effect as second-line therapy for hypertension Clinical question How effective are diuretics as second-line therapy for primary hypertension? Bottom line Thiazides as a second-line drug reduced blood (...) -blind randomised controlled trials (RCTs) evaluating loop diuretics were identified. These RCTs showed a BP lowering effect of about 6/3mmHg for a starting dose (piretanide 3mg/day and 6mg/day; frusemide 40mg/day). Caveat Due to the short duration of the trials (3Ð12 weeks) and lack of reporting of adverse events, this review does not provide a good estimate of the incidence of adverse effects of diuretics given as a second-line blood pressure lowering drug treatment. Context Even

2011 Cochrane PEARLS

19. Loop diuretics have modest efficacy in hypertension

Loop diuretics have modest efficacy in hypertension PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Loop diuretics have modest efficacy in hypertension Clinical question How effective are loop diuretics in the treatment of primary hypertension? Bottom line Based on the limited number of published randomised controlled trials, the blood pressure (BP) lowering effect of loop diuretics is modest (...) (-8/-4mmHg) compared with placebo. There was no clinically meaningful BP lowering differences between the 5 different loop diuretics (furosemide, cicletanine, piretanide, indacrinone and etozolin). The dose ranging effects of the diuretics could not be evaluated. There was no significant difference in withdrawals due to adverse effects and serum biochemical changes between loop diuretics and placebo. Caveat The BP lowering effect is likely to be an overestimate due to the high risk of bias

2011 Cochrane PEARLS

20. Acute kidney injury: prevention, detection and management

receptor antagonists [ARBs] and diuretics) within the past week, especially if hypovolaemic Acute kidney injury: prevention, detection and management (NG148) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 of 26use of iodine-based contrast media within the past week symptoms or history of urological obstruction, or conditions that may lead to obstruction sepsis deteriorating early warning scores age 65 years or over (...) of drugs that can cause or exacerbate kidney injury (such as NSAIDs, aminoglycosides, ACE inhibitors, ARBs and diuretics) within the past week, especially if hypovolaemic symptoms or history of urological obstruction, or conditions that may lead to obstruction sepsis a deteriorating paediatric early warning score severe diarrhoea (children and young people with bloody diarrhoea are at particular risk) Acute kidney injury: prevention, detection and management (NG148) © NICE 2019. All rights reserved

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines