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41. Clostridium difficile infection: risk with broad-spectrum antibiotics

or based on the sensitivities of causative bacteria. The Department of Health Advisory Committee on Antimicrobial Resistance and Healthcare Associated Infection (ARHAI) recommends the Start smart - then focus approach. This recommends that, if immediate antibiotic treatment is necessary, the clinical diagnosis and continuing need for antibiotics should be reviewed within 48-72 hours. When antibiotics are considered necessary to treat common infections in primary care, Public Health England's guidance (...) on managing common infections recommends suitable options and advises that broad-spectrum antibiotics should be used only when narrow-spectrum antibiotics are ineffective. Appropriate use of antimicrobials is also important to reduce the serious threat of antimicrobial resistance. A cross-governmental UK 5 year antimicrobial resistance strategy was launched in 2013. Full text of introduction and current guidance. Evidence review This evidence review outlines 1 meta-analysis of hospital-associated C

2015 National Institute for Health and Clinical Excellence - Advice

42. Antimicrobial prescribing: meropenem with vaborbactam

/50) of people receiving Antimicrobial prescribing: meropenem with vaborbactam (ES21) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 of 7meropenem with vaborbactam, and 44.0% (11/25) of people receiving best available antibiotic treatment. Adverse events leading to study treatment discontinuation occurred in 10.0% (5/50) and 12.0% (3/25) of people respectively. Statistical analyses were not reported for safety (...) for injection (Drug T ariff, October 2019). The cost of 1 day's treatment with 2 g (2 vials) every 8 hours is £106.68. The manufacturer of meropenem with vaborbactam (Menarini) anticipates that usage will be low, following the principles of good antimicrobial stewardship, and will be under the guidance of a microbiologist. A wide range of antibiotics, alone or in combination, are used for treating cUTI, acute pyelonephritis, cIAI, HAP and VAP , and regimens may be changed based on response to treatment

2019 National Institute for Health and Clinical Excellence - Advice

43. Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis

Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take (...) Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis Mohamed-Nur Abdallah, BDS, MSc, PhD . Overview Systematic Review Conclusion Despite the limited evidence and poor methodological quality of many included studies, antibiotic prophylaxis (AP) for patients at highest risk of developing infective endocarditis (IE) is a pragmatic and justified approach. However, postprocedural bacteremia may not be a good surrogate end point for IE. Critical Summary

2017 ADA Center for Evidence-Based Dentistry

44. XYDALBA (dalbavancin), antibiotic of the glycopeptide class

XYDALBA (dalbavancin), antibiotic of the glycopeptide class Haute Autorité de Santé - XYDALBA (dalbavancine), antibiotique de la classe des glycopeptides Développer la qualité dans le champ sanitaire, social et médico-social Recherche Évaluation & Recommandation La HAS Accréditation & Certification Outils, Guides & Méthodes Agenda Avis sur les Médicaments XYDALBA (dalbavancine), antibiotique de la classe des glycopeptides Substance active (DCI) dalbavancine (chlorhydrate de) INFECTIOLOGIE

2017 Haute Autorite de sante

45. Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis

Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take (...) Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis Mohamed-Nur Abdallah, BDS, MSc, PhD . Overview Systematic Review Conclusion Despite the limited evidence and poor methodological quality of many included studies, antibiotic prophylaxis (AP) for patients at highest risk of developing infective endocarditis (IE) is a pragmatic and justified approach. However, postprocedural bacteremia may not be a good surrogate end point for IE. Critical Summary

2017 ADA Center for Evidence-Based Dentistry

46. Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis

Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take (...) Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis Mohamed-Nur Abdallah, BDS, MSc, PhD . Overview Systematic Review Conclusion Despite the limited evidence and poor methodological quality of many included studies, antibiotic prophylaxis (AP) for patients at highest risk of developing infective endocarditis (IE) is a pragmatic and justified approach. However, postprocedural bacteremia may not be a good surrogate end point for IE. Critical Summary

2017 ADA Center for Evidence-Based Dentistry

47. Randomised controlled trial: Clinical failure is more common in young children with acute otitis media who receive a short course of antibiotics compared with standard duration (Full text)

otitis media who receive a short course of antibiotics compared with standard duration Article Text Therapeutics/Prevention Randomised controlled trial Clinical failure is more common in young children with acute otitis media who receive a short course of antibiotics compared with standard duration Roderick P Venekamp 1 , Anne G M Schilder 2 Statistics from Altmetric.com Commentary on: Hoberman A , Paradise JL , Rockette HE , et al . Shortened antimicrobial treatment for acute otitis media in young (...) children . Context Acute otitis media (AOM) is a leading cause of doctor consultations and antibiotic prescriptions in young children. 1 Strategies to reduce antibiotic prescribing for AOM and thereby the emerging spread of antimicrobial resistance have focused on watchful waiting and delayed prescription, in particular in children over 2 years. 2 An alternative strategy to combat antimicrobial resistance is to reduce the duration of antibiotic treatment. So far, the evidence to support this strategy

2017 Evidence-Based Medicine PubMed abstract

48. Cohort study: General practices that reduce antibiotic prescribing for self-limiting respiratory tract infections by 10% can expect to see one extra patient with pneumonia each year and one peritonsillar abscess each decade

Cohort study: General practices that reduce antibiotic prescribing for self-limiting respiratory tract infections by 10% can expect to see one extra patient with pneumonia each year and one peritonsillar abscess each decade General practices that reduce antibiotic prescribing for self-limiting respiratory tract infections by 10% can expect to see one extra patient with pneumonia each year and one peritonsillar abscess each decade | BMJ Evidence-Based Medicine We use cookies to improve our (...) * Password * your user name or password? You are here General practices that reduce antibiotic prescribing for self-limiting respiratory tract infections by 10% can expect to see one extra patient with pneumonia each year and one peritonsillar abscess each decade Article Text Therapeutics/Prevention Cohort study General practices that reduce antibiotic prescribing for self-limiting respiratory tract infections by 10% can expect to see one extra patient with pneumonia each year and one peritonsillar

2017 Evidence-Based Medicine

49. Adjunctive antibiotics for drained skin abscesses improve clinical cure rate

Adjunctive antibiotics for drained skin abscesses improve clinical cure rate Adjunctive antibiotics for drained skin abscesses improve clinical cure rate | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts (...) Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Adjunctive antibiotics for drained skin abscesses improve clinical cure rate Article Text Commentary: General medicine Adjunctive antibiotics for drained skin abscesses improve clinical cure rate David A Talan Statistics from

2017 Evidence-Based Medicine

50. Prescribing antibiotics to hospitalised patients increases the risk of Clostridium difficile infection for the next bed occupant

Prescribing antibiotics to hospitalised patients increases the risk of Clostridium difficile infection for the next bed occupant Prescribing antibiotics to hospitalised patients increases the risk of Clostridium difficile infection for the next bed occupant | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our (...) . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Prescribing antibiotics to hospitalised patients increases the risk of Clostridium difficile infection for the next bed occupant

2017 Evidence-Based Medicine

51. Antibiotics Do Not Lower Pain or Infection with Acute Apical Abscess

Antibiotics Do Not Lower Pain or Infection with Acute Apical Abscess UTCAT3216, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Antibiotics Do Not Lower Pain or Infection with Acute Apical Abscess Clinical Question In adults receiving emergency treatment for their periapical abscess, will antibiotic supplement to pulpectomy treatment with irrigation and drainage of their abscess be more beneficial in reducing (...) the patient's pain compared to treatment without antibiotics? Clinical Bottom Line Pain with acute apical abscess of permanent dentition is managed well by pulpectomy with irrigation and drainage. The addition of antibiotic therapy does not improve the patient's relief from pain or infection. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Matthews/2003 35 relevant citations including 8 randomized clinical

2017 UTHSCSA Dental School CAT Library

52. Covid-19: Antimicrobial Copper Oxide–infused Textiles for Reducing Healthcare-associated Infection Risk

copper oxide–infused textiles. Clinical Literature We searched PubMed, EMBASE, Google Scholar, the Cochrane Library, and selected web-based resources for documents relevant to this topic and published between January 1, 2006, and February 5, 2019. Our search strategies included the following keywords: copper; fabric; textiles; bedding; clothing; antimicrobial; antibacterial; infection control. Please see the Selected References and Resources section for detailed search strategies. We included any (...) , labor, and laundry, expenses during period B.” “The use of biocidal copper oxide impregnated textiles in a long-term care ward may significantly reduce HAI, fever, antibiotic consumption, and related treatment costs.” CLINICAL EVIDENCE ASSESSMENT Antimicrobial Copper Oxide–infused Textiles for Reducing Healthcare-associated Infection Risk © February 2019 ECRI | 6 Selected References and Resources References Reviewed (PubMed and EMBASE search dates were January 1, 2006, through February 5, 2019) 1

2020 Covid-19 Ad hoc papers

53. Dental antimicrobial stewardship: toolkit

Dental antimicrobial stewardship: toolkit Dental antimicrobial stewardship: toolkit - GOV.UK GOV.UK uses cookies to make the site simpler. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Dental antimicrobial stewardship: toolkit Resources to help primary care practitioners promote the appropriate use of antibiotics in dental care. Published 9 November 2016 Last updated 16 July 2019 — From: Contents The dental antimicrobial stewardship ( ( ( Guidance (...) ( Education and training tools Audit tool and action planning An audit tool developed as a collaboration between Why the toolkit was developed The inappropriate use of antibiotics is related to bacterial resistance. Responsible use of antimicrobials should help control it. The toolkit aims to influence prescribers and patients attitudes to enable optimal antibiotic prescribing. An independent review of antimicrobial resistance, the commissioned by the UK Government in 2014 and chaired by Lord Jim O’Neill

2020 Public Health England

54. Practical advice on maintaining antimicrobial stewardship during the COVID-19 pandemic

Practical advice on maintaining antimicrobial stewardship during the COVID-19 pandemic SAPG response to COVID-19 Latest updates / / / 13 May 2020 SAPG response to COVID-19 To prioritise and support the capacity of health and social care services, Healthcare Improvement Scotland and the Scottish Antimicrobial Prescribing Group (SAPG) have taken the decision to adapt our normal ways of working. This action is supported by Scottish Government. This is an unprecedented situation requiring unusual (...) measures, and that it is important that SAPG supports NHSScotland in maintaining essential services. All meetings of the SAPG committee and project groups have been suspended until further notice. The duration of these measures is unknown and we will provide further updates in due course. In the interim, if you have any queries, please contact: We have developed some interim pragmatic practical advice for clinical teams to ensure we maintain antimicrobial stewardship during the COVID-19 pandemic

2020 Covid-19 Ad hoc papers

55. Antimicrobial Nano-Silver Sanitizer Spray

of nanotechnology. 3 Silver was known for its antibacterial effect and silver-based compounds have been used in many antimicrobial applications. 4,5 By converting bulk silver to nanosized silver, its effectiveness for controlling bacteria and viruses was increased multifold. 2 Due to their bactericidal properties, silver nanoparticles (AgNP) are the most frequently applied nanomaterials, attracting much interest and has the highest degree of commercialisation. 5,6,7 The unique property of nanosilver is mainly (...) Antimicrobial Nano-Silver Sanitizer Spray To provide brief information on the safety, effectiveness and cost-effectiveness of Antimicrobial Nano-Silver Sanitizer Spray based on request from the Director General of Health, Ministry of Health Malaysia following proposal by a company to provide and distribute 500,000 Antimicrobial Nano-Silver Sanitizer Spray to the public, beginning with Ministry of Health Malaysia hospitals and clinics to prevent COVID-19 transmission. Nanoparticles include

2020 MaHTAS Covid-19 Rapid Evidence Updates

56. Quantitative study?other: Structured antibiotic ?time-out? audits as recommended by the CDC reduce antibiotic use and costs (Full text)

-out’ audits as recommended by the CDC reduce antibiotic use and costs Peter G Davey Statistics from Altmetric.com Commentary on: Lee TC , Frenette C , Jayaraman D et al . Antibiotic self-stewardship: trainee-led structured antibiotic time-outs to improve antimicrobial use . Implications for practice and research Self-monitoring is a highly effective behaviour change technique, which should be more widely used in improving prescribing in hospitals and more generally in changing professional (...) Quantitative study?other: Structured antibiotic ?time-out? audits as recommended by the CDC reduce antibiotic use and costs Structured antibiotic ‘time-out’ audits as recommended by the CDC reduce antibiotic use and costs | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password

2016 Evidence-Based Nursing PubMed abstract

57. Antimicrobial resistance (AMR): applying All Our Health

prevent ill health and promote wellbeing as part of their everyday practice. The information below will help front-line health and care staff use their trusted relationships with patients, families and communities to promote the benefits of preventing antimicrobial resistance ( of ‘All Our Health’ topics. Infections that cannot be treated continue to develop. The rapid spread of multidrug resistant organisms means that we may not be able to treat everyday infections or diseases with antibiotics (...) in the near future. Many existing antimicrobials are becoming less effective as bacteria, viruses, protozoa and fungi are adapting and becoming resistant to medicines. Inappropriate use of these valuable medicines has also added to the problem. Without effective antibiotics, even minor surgery and routine operations could become high risk procedures if serious infections can’t be treated. Access the antimicrobial resistance e-learning session An is now available to use. and 5 Year Action Plan set out

2019 Public Health England

58. Use of a procalcitonin algorithim to guide antimicrobial therapy in COPD exacerbations can reduce antibiotic consumption with no increase in rates of treatment failure or mortality

Use of a procalcitonin algorithim to guide antimicrobial therapy in COPD exacerbations can reduce antibiotic consumption with no increase in rates of treatment failure or mortality BestBets: Use of a procalcitonin algorithim to guide antimicrobial therapy in COPD exacerbations can reduce antibiotic consumption with no increase in rates of treatment failure or mortality Use of a procalcitonin algorithim to guide antimicrobial therapy in COPD exacerbations can reduce antibiotic consumption (...) of procalcitonin and the presence of bacterial infection. What is less clear is whether using procalcitonin at predefined cut-offs in the emergency department is a safe and effective strategy to guide antibiotic prescription. The data reviewed here suggest that procalcitonin may be used to guide therapy without an increased rate of death or other adverse outcomes such as prolonged hospital stay, intensive care unit admission or re-exacerbation. This could serve to promote antimicrobial stewardship, decrease

2015 BestBETS

59. The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis

The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club

60. Anthim (obiltoxaximab) - To treat inhalational anthrax in combination with appropriate antibacterial drugs

Anthim (obiltoxaximab) - To treat inhalational anthrax in combination with appropriate antibacterial drugs Anthim (obiltoxaximab) Injection U.S. Department of Health and Human Services Search FDA Submit search Anthim (obiltoxaximab) Injection Anthim (obiltoxaximab) Injection Company: Elusys Therapeutics, Inc. Application No.: 125509 Approval Date: 03/18/2016 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF

2016 FDA - Drug Approval Package

Evidence-based Synopses

Synopses are typically easily digested, critical commentaries of articles e.g. critically appraised topics.