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1. Antibiotic awareness: important messages on antibiotic use

Antibiotic awareness: important messages on antibiotic use Antibiotic awareness: important messages on antibiotic use - GOV.UK GOV.UK uses cookies which are essential for the site to work. We also use non-essential cookies to help us improve government digital services. Any data collected is anonymised. By continuing to use this site, you agree to our use of cookies. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Antibiotic awareness: important messages (...) on antibiotic use This document explains how to use antibiotics responsibly for patients, animal keepers, pet owners and prescribers. Published 23 September 2014 Last updated 7 October 2019 — From: Documents Ref: PHE publication gateway reference: GW-779 If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email . Please tell us what format you need. It will help us if you say what assistive technology you use. Details PHE has

2019 Public Health England

2. There?s Pus About, So Are Antibiotics In or Out? Adding antibiotics for abscess management

There?s Pus About, So Are Antibiotics In or Out? Adding antibiotics for abscess management Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 5,000 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care (...) research. www.acfp.ca January 21, 2019 There’s Pus About, So Are Antibiotics In or Out? Adding antibiotics for abscess management Clinical Question: Does the addition of antibiotics to incision and drainage improve cure rates in single, uncomplicated skin abscesses? Bottom Line: Adding antibiotics that cover MRSA during incision and drainage for a small abscess increases the cure rate from 85% to 92%, meaning an additional one in 15 patients will be cured compared to placebo at one month. Approximately

2019 Tools for Practice

3. Primary care: Broad-spectrum antibiotics gave no clinical benefit and more adverse effects than narrow-spectrum antibiotics in treating acute respiratory tract infections in US children

no clinical benefit and more adverse effects than narrow-spectrum antibiotics in treating acute respiratory tract infections in US children Morten Lindbaek Statistics from Altmetric.com Commentary on : Gerber JS, Ross RK, Bryan M, et al . Association of Broad- vs Narrow-Spectrum Antibiotics With Treatment Failure, Adverse Events, and Quality of Life in Children With Acute Respiratory Tract Infections. JAMA. 2017 Dec 19;318:2325–2336. Context Antimicrobial prescribing is associated with higher levels (...) of resistance; a linear trend by nation has been presented. 1 Large variations in antimicrobial prescribing between countries have been demonstrated, the USA is in line with top EU countries like Greece and France, using three times more per inhabitant than the Nordic countries. Respiratory tract infections (RTIs) in primary care are frequently viral, and a large proportion of bacterial infections such as otitis media, sinusitis and sore throat have little benefit from antibiotic treatment. Another

2019 Evidence-Based Medicine

4. What is the evidence for use of macrolide antibiotics for treatment of COVID-19?

that has complicated COVID-19, we recognise that clinicians may wish to prescribe macrolide antibiotics, in line with their local/national antimicrobial guidelines. End. Disclaimer : This article has not been peer-reviewed; it should not replace individual clinical judgement and the sources cited should be checked. The views expressed in this commentary represent the views of the authors and not necessarily those of the host institution, the NHS, the NIHR, or the Department of Health and Social Care (...) What is the evidence for use of macrolide antibiotics for treatment of COVID-19? What is the evidence for use of macrolide antibiotics for treatment of COVID-19? - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website What is the evidence for use of macrolide antibiotics for treatment of COVID-19? April 28, 2020 Kome Gbinigie and Kerstin Frie On behalf of the Oxford COVID-19 Evidence Service Team Centre

2020 Oxford COVID-19 Evidence Service

5. What Is the Utility of Prophylactic Antibiotics for Patients After Cardiac Arrest? Full Text available with Trip Pro

on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke. Resuscitation . 2008 ; 79 : 350–379 | | | | | Consequently, prophylactic antibiotics may seem reasonable in this population. However, it is important to balance this against the need for antimicrobial stewardship. Although this study demonstrated (...) What Is the Utility of Prophylactic Antibiotics for Patients After Cardiac Arrest? What Is the Utility of Prophylactic Antibiotics for Patients After Cardiac Arrest? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 75, Issue 1, Pages 102–104 What Is the Utility of Prophylactic Antibiotics for Patients After Cardiac Arrest? x Michael Gottlieb , MD (EBEM Commentator) , x Trevor Landas , MD (EBEM

2020 Annals of Emergency Medicine Systematic Review Snapshots

6. Do Antibiotics Improve Outcomes in Patients With Acute Asthma Exacerbations? Full Text available with Trip Pro

Do Antibiotics Improve Outcomes in Patients With Acute Asthma Exacerbations? Do Antibiotics Improve Outcomes in Patients With Acute Asthma Exacerbations? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 74, Issue 5, Pages 711–712 Do Antibiotics Improve Outcomes in Patients With Acute Asthma Exacerbations? x Latha Ganti , MD, MBA (EBEM Commentator) , x Javier Rosario , MD (EBEM Commentator) Department (...) of Emergency Medicine, Envision Physician Services, University of Central Florida College of Medicine, Orlando, FL DOI: | Publication History Published online: April 11, 2019 Expand all Collapse all Article Outline Take-Home Message Moderate- to low-quality evidence suggests that antibiotics may reduce symptoms and improve pulmonary function but do not improve other outcomes in patients with acute asthma exacerbations. Methods Data Sources MEDLINE, EMBASE, the Cumulative Index of Nursing and Allied Health

2020 Annals of Emergency Medicine Systematic Review Snapshots

7. Do Antibiotics Improve Patient Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease? Full Text available with Trip Pro

Do Antibiotics Improve Patient Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease? Do Antibiotics Improve Patient Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 74, Issue 5, Pages e79–e81 Do Antibiotics Improve Patient Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease? x Brit Long (...) , MD (EBEM Commentator) , x Michael D. April , MD, DPhil (EBEM Commentator) Department of Emergency Medicine, San Antonio Uniformed Services Health Education Consortium, Fort Sam Houston, TX DOI: | Publication History Published online: February 14, 2019 Expand all Collapse all Article Outline Take-Home Message For patients with acute chronic obstructive pulmonary disease exacerbation, antibiotics reduce treatment failure for those with mild to moderate exacerbations. Antibiotics reduce mortality

2020 Annals of Emergency Medicine Systematic Review Snapshots

8. Triple Antibiotic Solution Promotes Similar Antibacterial Effects as Calcium Hydroxide/2% Chlorhexidine When Used as an Intracanal Medicament

instrumentation and/or irrigation, are effective in canal disinfection. The intracanal antimicrobial efficacy of triple antibiotic formulation is shown to be superior to calcium hydroxide alone, or at least comparable to calcium hydroxide combined with 2% chlorhexidine when assessing antibacterial efficacy and clinical outcomes. Perspective: Randomized clinical trials are currently the highest available evidence comparing use of triple antibiotic paste against other canal medicaments in primary teeth (...) Triple Antibiotic Solution Promotes Similar Antibacterial Effects as Calcium Hydroxide/2% Chlorhexidine When Used as an Intracanal Medicament UTCAT3361, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Triple Antibiotic Solution Promotes Similar Antibacterial Effects as Calcium Hydroxide/2% Chlorhexidine When Used as an Intracanal Medicament Clinical Question In patients undergoing non-surgical therapy in a tooth

2018 UTHSCSA Dental School CAT Library

9. COPD exacerbation: no systematic use of antibiotics

COPD exacerbation: no systematic use of antibiotics Prescrire IN ENGLISH - Spotlight ''COPD exacerbation: no systematic use of antibiotics'', 1 January 2019 {1} {1} {1} | | > > > COPD exacerbation: no systematic use of antibiotics Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight COPD exacerbation: no systematic use of antibiotics For episodes (...) of moderate aggravation in patients with chronic obstructive pulmonary disease (COPD), it is preferable to prescribe antibiotics as a first-line treatment only when the suspicion of bacterial infection is reinforced by an increase in sputum purulence. Patients with chronic obstructive pulmonary disease (COPD) are subject to exacerbations of their disease, i.e. episodes of prolonged aggravation. The known causes are mainly viral and bacterial infections. Some exacerbations justify hospitalisation: severe

2019 Prescrire

10. Are Antibiotics Effective in the Treatment of Children With Prolonged Wet Cough? Full Text available with Trip Pro

Are Antibiotics Effective in the Treatment of Children With Prolonged Wet Cough? Are Antibiotics Effective in the Treatment of Children With Prolonged Wet Cough? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 73, Issue 5, Pages 453–455 Are Antibiotics Effective in the Treatment of Children With Prolonged Wet Cough? x Brit Long , MD (EBEM Commentator) , x Michael D. April , MD, DPhil (EBEM (...) Commentator) Department of Emergency Medicine, San Antonio Uniformed Services Health Education Consortium, Fort Sam Houston, TX DOI: | Publication History Published online: November 13, 2018 Expand all Collapse all Article Outline Take-Home Message Antibiotics may improve clinical cure and reduce progression of illness in children with prolonged wet cough. Methods Data Sources Authors identified trials from the Cochrane Airways Trials Register, CENTRAL, MEDLINE OvidSP, and EMBASE OvidSP through September

2019 Annals of Emergency Medicine Systematic Review Snapshots

11. Probiotics for Antibiotic-Associated Diarrhea in Pediatrics: A Review of Clinical Effectiveness and Guidelines

Probiotics for Antibiotic-Associated Diarrhea in Pediatrics: A Review of Clinical Effectiveness and Guidelines Probiotics for Antibiotic-Associated Diarrhea in Pediatrics: A Review of Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Probiotics for Antibiotic-Associated Diarrhea in Pediatrics: A Review of Clinical Effectiveness and Guidelines Probiotics for Antibiotic-Associated Diarrhea in Pediatrics: A Review of Clinical Effectiveness and Guidelines Last updated (...) : March 25, 2019 Project Number: RC1086-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of probiotics (with or without concurrent antibiotics) for preventing and treating antibiotic-associated diarrhea in the pediatric population? What are the evidence-based guidelines regarding the use of probiotics (with or without concurrent antibiotics) for the prevention and treatment of antibiotic-associated

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

12. Biologics versus Immunomodulators or Antibiotics for the Management of Fistulizing Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness

Biologics versus Immunomodulators or Antibiotics for the Management of Fistulizing Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness Biologics versus Immunomodulators or Antibiotics for the Management of Fistulizing Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness | CADTH.ca Find the information you need Biologics versus Immunomodulators or Antibiotics for the Management of Fistulizing Crohn’s Disease: A Review (...) of Comparative Clinical Effectiveness and Cost-Effectiveness Biologics versus Immunomodulators or Antibiotics for the Management of Fistulizing Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness Last updated: March 29, 2019 Project Number: RC1107-000 - RD0051-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative clinical effectiveness of biologics (with or without concomitant immunomodulators

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

13. Obtaining Blood Cultures Before the Administration of Antibiotics and other Emergency Department Fables: An Analysis of the FABLED Study Full Text available with Trip Pro

obtained before starting antibiotic therapy, and who were able to have additional sets obtained within 2 hours of empirical antimicrobial administration. Severe manifestations of sepsis were defined by 2 SIRS criteria, with a suspected or confirmed infectious source, and either hypotension (systolic blood pressure <90 mm Hg) or a serum lactate level greater than 4 mmol/L. Intervention: Two sets of blood cultures (1 aerobic and 1 anaerobic culture vial in each set) were obtained before antimicrobial (...) administration from separate venipuncture sites. Patients were required to have repeated blood testing for cultures, obtained between 30 and 120 minutes after the initiation of antibiotic therapy. Primary and Secondary Outcomes: Sensitivity of blood culture results obtained after initiation of antimicrobial therapy. Sponsors: Vancouver Coastal Health, St. Paul’s Hospital Foundation Emergency Department Support Fund, the Fonds de recherche Santé–Quebec, and the Maricopa Medical Foundation. ClinicalTrials.gov

2020 Annals of Emergency Medicine Journal Club

14. Guideline on the prudent prescription of antibiotics in the dental office

2.6.2 Systematic reviews 31 2.6.3 RCTs 31 2.6.4 Non-randomised primary studies 31 2.7 DATA EXTRACTION 32 2.8 STATISTICAL ANALYSES 32 2.9 GRADING EVIDENCE 32 2.10 FORMULATION OF RECOMMENDATIONS 35 2.11 STAKEHOLDER INVOLVEMENT 38 2.11.1 Professional associations 38 2.11.2 Patient representatives 39 2.11.3 Process 40 2.12 FINAL VALIDATION 40 3 ADVERSE EVENTS ASSOCIATED WITH THE USE OF ANTIBIOTICS 41 3.1 ANTIBACTERIAL RESISTANCE 42 3.1.1 Antibacterial resistance, a natural phenomenon 42 3.1.2 How do (...) bacteria become resistant? 42 3.1.3 How does antibiotic resistance spread? 43 3.1.4 The burden of antibacterial resistance 43 3.1.5 The prudent use of antibiotics, an essential element in the battle against antibacterial resistance 47 3.2 DISRUPTION OF THE HUMAN MICROBIOME 47 3.2.1 The human microbiome 47 KCE Report 332 Prescription of antibiotics in the dental office 3 3.2.2 Impact of antibiotics on the human microbiome 48 3.2.3 Clostridioides difficile infection following antibiotic use 48 3.3 DRUG

2020 Belgian Health Care Knowledge Centre

15. COVID-19: Antibiotic Management in Ambulatory Patients

April 3 The CDC offers no guidance specific to the use of antibiotics in COVID+ patients in the outpatient setting. Professional society guidance on antibiotic indications in COVID+ patients or patients under investigation (PUI) Source Recommendations IDSA April 13 The IDSA offers no guidance specific to the use of antibiotics in COVID+ patients in the outpatient setting. ASP April 2 For patients in an ambulatory setting, antibacterial therapy (including azithromycin) is not routinely recommended (...) COVID-19: Antibiotic Management in Ambulatory Patients COVID-19: ANTIBIOTIC MANAGEMENT IN AMBULATORY PATIENTS A Rapid Guidance Summary from the Penn Medicine Center for Evidence-based Practice Last updated April 21, 2020 1:00 pm. Sources rechecked April 19 unless otherwise noted. Key questions answered in this summary • What are indications for antibiotic use in COVID-19 patients being cared for in the ambulatory setting? • What are best practices related to antibiotic management

2020 Centre for Evidence-Based Practice, Penn Medicine

16. Antibiotic prescribing - especially broad spectrum antibiotics

or moderately severe infections unless other antibacterial medicines commonly recommended for these infections cannot be used. Fluoroquinolone antibiotics should be avoided when treating infections in people who have previously experienced serious adverse events with fluoroquinolones. They should be used with Antimicrobial stewardship: prescribing antibiotics (KTT9) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 (...) Antibiotic prescribing - especially broad spectrum antibiotics Antimicrobial stewardship: prescribing Antimicrobial stewardship: prescribing antibiotics antibiotics Key therapeutic topic Published: 15 January 2015 nice.org.uk/guidance/ktt9 pathways K Ke ey points y points Antimicrobial resistance poses a significant global threat to public health, especially because antimicrobials underpin routine medical practice. Addressing antimicrobial resistance through improving stewardship is a national

2015 National Institute for Health and Clinical Excellence - Advice

17. Proposals for a more effective antibiotic policy in Belgium

(BAPCOC) 24 1.1.6 Difficult to obtain significant improvements 24 1.2 RESEARCH QUESTIONS & SCOPE 25 1.3 TERMINOLOGY 25 1.4 METHODOLOGY 26 1.5 STRUCTURE OF THE REPORT 26 2 ANTIBIOTIC USE AND ITS LINK WITH ANTIBACTERIAL RESISTANCE 27 2.1 WHAT IS ANTIMICROBIAL RESISTANCE? 27 2.1.1 Antibacterial resistance, a natural phenomenon 27 2.1.2 How do bacteria become resistant? 27 2.1.3 How does antibiotic resistance spread? 28 2.1.4 Multidrug resistant organisms 28 2.1.1 Resistance in community and healthcare (...) . This document is available on the website of the Belgian Health Care Knowledge Centre. KCE Report 311 Antibiotic policy in Belgium 1 ? TABLE OF CONTENTS LIST OF FIGURES 8 LIST OF TABLES 10 LIST OF ABBREVIATIONS 13 ? SCIENTIFIC REPORT 23 1 INTRODUCTION 23 1.1 SHORT DESCRIPTION OF THE PROBLEM 23 1.1.1 Antibiotic resistance 23 1.1.2 Antibiotic use in Belgium 24 1.1.3 The concept of prudent antimicrobial/antibiotic use 24 1.1.4 One Health approach 24 1.1.5 Belgian Antibiotic Policy Coordination Committee

2019 Belgian Health Care Knowledge Centre

18. Procalcitonin and Antibiotics for Lower Respiratory Tract Infections

Procalcitonin and Antibiotics for Lower Respiratory Tract Infections Procalcitonin and Antiobiotics for Lower Respiratory Tract Infections | Emergency Medicine | Washington University in St. Louis Open Menu Back Close Menu Search for: Loading... Welcome Sections Education Fellowships Alumni Research ECRC Journal Club Events Lewis Health Policy Symposia Jermyn Lectures Open Search Article 2: Schuetz P, Wirz Y, Sager R, et al. Procalcitonin to initiate or discontinue antibiotics in acute (...) respiratory tract infections. Cochrane Database Syst Rev. 2017 Oct 12;10:CD007498. Article 3: Huang DT, Yealy DM, Filbin MR, et al: ProACT Investigators. Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection. N. Engl J Med. 2018 Jul 19;379(3): 236-249 Article 4: Walsh EE, Swinburne AJ, Becker KL, et al. Can serum procalcitonin levels help interpret indeterminate chest radiographs in patients hospitalized with acute respiratory illness? J Hosp Med. 2013 Feb;8(2): 61-7 Bottom Line

2018 Washington University Emergency Medicine Journal Club

19. Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects

and tendon rupture report suspected adverse drug reactions to fluoroquinolone antibiotics on the or via the Yellow Card app (download it from the , or ) New restricted indications Fluoroquinolones are antibiotics authorised for serious, life-threatening bacterial infections. As for all antibiotic medicines, consideration should be given to official guidance on the appropriate use of antibacterial agents (see section below on Prescribing guidance). Following an EU-wide review of safety, new restricted (...) Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports

2019 MHRA Drug Safety Update

20. Probiotics for Antibiotic-Associated Diarrhea and Clostridium difficile Infection: A Review of Guidelines

Probiotics for Antibiotic-Associated Diarrhea and Clostridium difficile Infection: A Review of Guidelines Probiotics for Antibiotic-Associated Diarrhea and Clostridium difficile Infection: A Review of Guidelines | CADTH.ca Find the information you need Probiotics for Antibiotic-Associated Diarrhea and Clostridium difficile Infection: A Review of Guidelines Probiotics for Antibiotic-Associated Diarrhea and Clostridium difficile Infection: A Review of Guidelines Last updated: September 6, 2018 (...) Project Number: RC1013-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What are the evidence-based guidelines regarding the use of probiotics for the prevention, management, and treatment of antibiotic-associated diarrhea and C. difficile infection? Key Message One guideline recommended the use of probiotics for treatment of antibiotic associated diarrhea (varying strength of recommendation depending on the product).Four guidelines did

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

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