Does BMI affect the effectiveness of DMPA contraceptive injection?
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- Answered 30 May 2019 Conflict of interest declaration: None The Faculty of Sexual and Reproductive Healthcare have a guideline ‘Overweight, Obesity and Contraception’ (https://www.fsrh.org/standards-and-guidance/documents/fsrh-clinical-guideline-overweight-obesity-and-contraception/1overweight-obesity-and-contraception-guideline-april-2019.pdf) where they report: The available evidence suggests that effectiveness of depot medroxyprogesterone acetate (DMPA) is not affected by body weight or BMI. From the limited evidence available it is not possible to confirm or exclude a causal association between DMPA use and venous thromboembolism (VTE). Whilst obesity alone does not restrict the use of DMPA (UKMEC 1), DMPA use becomes a UKMEC 3 when obesity is one of multiple risk factors for cardiovascular disease (e.g. smoking, diabetes and hypertension). DMPA use appears to be associated with some weight gain, particularly in women under 18 years of age with a BMI ≥30 kg/m2.