Latest & greatest articles for sepsis

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This page lists the very latest high quality evidence on sepsis and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Top results for sepsis

1. Inclusion of women in sepsis research: a bibliometric analysis from systematic reviews and guidelines

Inclusion of women in sepsis research: a bibliometric analysis from systematic reviews and guidelines Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2020 PROSPERO

2. Restrictive versus liberal fluid therapy for sepsis

Restrictive versus liberal fluid therapy for sepsis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith

2020 PROSPERO

3. The global burden of sepsis in neonates - update of a systematic review and meta-analysis

The global burden of sepsis in neonates - update of a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2020 PROSPERO

4. The effects of Xuebijing injections on the mortality of patients with sepsis or septic shock

The effects of Xuebijing injections on the mortality of patients with sepsis or septic shock Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2020 PROSPERO

5. Enteral lactoferrin supplementation for prevention of sepsis in preterm infants: a systematic review and meta-analysis

Enteral lactoferrin supplementation for prevention of sepsis in preterm infants: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2020 PROSPERO

6. Association between macrophage migration inhibitory factor and the severity and outcome of sepsis

Association between macrophage migration inhibitory factor and the severity and outcome of sepsis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2020 PROSPERO

7. The Combined SIRS + qSOFA (qSIRS) Score is More Accurate Than qSOFA Alone in Predicting Mortality in Patients with Surgical Sepsis in an LMIC Emergency Department (Abstract)

The Combined SIRS + qSOFA (qSIRS) Score is More Accurate Than qSOFA Alone in Predicting Mortality in Patients with Surgical Sepsis in an LMIC Emergency Department qSOFA has been proposed as a prognostic tool in patients with sepsis. This study set out to assess the sensitivity of several scores, namely: the pre-ICU qSOFA, the qSOFA with lactate (qSOFA L), SIRS score, qSOFA + SIRS score (qSIRS) and qSIRS with lactate (qSIRS L) in predicting in-hospital mortality in patients with surgical sepsis (...) as well as the sensitivity of these scores in predicting high-grade sepsis. The secondary aim was to determine which of these scores is best suited to predict high-grade surgical sepsis.This was a retrospective cohort study that was conducted between December 2012 and August 2017 in a public metropolitan surgical service. Data from patients aged > 13 years, who were admitted to the hospital and who had an emergency surgical procedure for source control were retrieved from a prospectively maintained

2019 EvidenceUpdates

8. Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial. Norepinephrine, the first-line vasopressor for septic shock, is not always effective and has important catecholaminergic adverse effects. Selepressin, a selective vasopressin V1a receptor agonist, is a noncatecholaminergic vasopressor that may mitigate sepsis-induced vasodilatation, vascular leakage, and edema, with fewer adverse effects.To test

2019 JAMA

9. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial. (Abstract)

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial. Experimental data suggest that intravenous vitamin C may attenuate inflammation and vascular injury associated with sepsis and acute respiratory distress syndrome (ARDS).To determine the effect of intravenous vitamin C infusion on organ failure scores and biological markers of inflammation (...) and vascular injury in patients with sepsis and ARDS.The CITRIS-ALI trial was a randomized, double-blind, placebo-controlled, multicenter trial conducted in 7 medical intensive care units in the United States, enrolling patients (N = 167) with sepsis and ARDS present for less than 24 hours. The study was conducted from September 2014 to November 2017, and final follow-up was January 2018.Patients were randomly assigned to receive intravenous infusion of vitamin C (50 mg/kg in dextrose 5% in water, n = 84

2019 JAMA

10. Detection and Diagnosis of Sepsis in Rural and Remote Areas: An Environmental Scan

Detection and Diagnosis of Sepsis in Rural and Remote Areas: An Environmental Scan Detection and Diagnosis of Sepsis in Rural and Remote Areas: An Environmental Scan | CADTH.ca Find the information you need Detection and Diagnosis of Sepsis in Rural and Remote Areas: An Environmental Scan Detection and Diagnosis of Sepsis in Rural and Remote Areas: An Environmental Scan Last updated: January 9, 2019 Project Number: ES0327-000 Product Line: Result type: Report CADTH undertook an Environmental (...) Scan to understand current practices for detecting and diagnosing sepsis in remote and rural health care settings across Canada. The key objectives of this Environmental Scan were: To describe the current guidance (i.e., policies, protocols, guidelines, algorithms) for detecting and diagnosing sepsis in rural and remote health care settings in Canada To describe current practice for detecting and managing sepsis in rural and remote health care settings in Canada and how this compares to recommended

2019 Canadian Agency for Drugs and Technologies in Health - Environmental Scanning

11. Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety: A Systematic Review and Meta-analysis (Abstract)

Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety: A Systematic Review and Meta-analysis The neonatal early-onset sepsis (EOS) calculator is a clinical risk stratification tool increasingly used to guide the use of empirical antibiotics for newborns. Evidence on the effectiveness and safety of the EOS calculator is essential to inform clinicians considering implementation.To assess the association between management of neonatal EOS

2019 EvidenceUpdates

12. Screening Triage Tools and Management Algorithms for Adult Sepsis Patients: Clinical Utility and Guidelines

Screening Triage Tools and Management Algorithms for Adult Sepsis Patients: Clinical Utility and Guidelines Screening Triage Tools and Management Algorithms for Adult Sepsis Patients: Clinical Utility and Guidelines | CADTH.ca Find the information you need Screening Triage Tools and Management Algorithms for Adult Sepsis Patients: Clinical Utility and Guidelines Screening Triage Tools and Management Algorithms for Adult Sepsis Patients: Clinical Utility and Guidelines Last updated: August 13 (...) , 2019 Project Number: RA1058-000 Product Line: Research Type: Devices and Systems Report Type: Reference List Result type: Report Question What is the clinical utility of screening triage tools and/or management algorithms in adult patients in the emergency department with suspected sepsis? What is the clinical utility of screening triage tools and/or management algorithms in adult inpatients with suspected sepsis? What are the evidence-based guidelines regarding the use of screening triage tools

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

13. Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis: A Diagnostic Study. (Abstract)

Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis: A Diagnostic Study. Administering antimicrobial agents before obtaining blood cultures could potentially decrease time to treatment and improve outcomes, but it is unclear how this strategy affects diagnostic sensitivity.To determine the sensitivity of blood cultures obtained shortly after initiation of antimicrobial therapy in patients with severe manifestations (...) of sepsis.Patient-level, single-group, diagnostic study. (ClinicalTrials.gov: NCT01867905).7 emergency departments in North America.Adults with severe manifestations of sepsis, including systolic blood pressure less than 90 mm Hg or a serum lactate level of 4 mmol/L or more.Blood cultures were obtained before and within 120 minutes after initiation of antimicrobial treatment.Sensitivity of blood cultures obtained after initiation of antimicrobial therapy.Of 3164 participants screened, 325 were included

2019 Annals of Internal Medicine

14. Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis. Full Text available with Trip Pro

Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis. Beginning in 2013, New York State implemented regulations mandating that hospitals implement evidence-based protocols for sepsis management, as well as report data on protocol adherence and clinical outcomes to the state government. The association between these mandates and sepsis outcomes is unknown.To evaluate the association between New York State sepsis regulations (...) and the outcomes of patients hospitalized with sepsis.Retrospective cohort study of adult patients hospitalized with sepsis in New York State and in 4 control states (Florida, Maryland, Massachusetts, and New Jersey) using all-payer hospital discharge data (January 1, 2011-September 30, 2015) and a comparative interrupted time series analytic approach.Hospitalization for sepsis before (January 1, 2011-March 31, 2013) vs after (April 1, 2013-September 30, 2015) implementation of the 2013 New York State sepsis

2019 JAMA

15. Diagnostic value of neutrophil CD64 combined with CRP for neonatal sepsis: A meta-analysis (Abstract)

Diagnostic value of neutrophil CD64 combined with CRP for neonatal sepsis: A meta-analysis Sepsis is the leading cause of morbidity and mortality in newborns. CD64 combined with c-reactive protein (CRP) could improve the sensitivity and specificity of neonatal sepsis diagnosis, but the results were still controversial. Therefore, this meta-analysis was conducted to clarify the importance of CD64 combined with CRP in the diagnosis of neonatal sepsis.The researches published as of December 24 (...) ), 0.06 (95% CI: 0.02-0.18); diagnostic odds ratio (DOR), 118.0 (95% CI: 25.00-549.00), and the area under the curve (AUC) was 0.96 (95% CI: 0.94-0.97). It was found that heterogeneity was not caused by threshold effect (P = 0.16), but the results of sensitivity (I2 = 87.57%) and specificity (I2 = 89.07%) analyses indicated significant heterogeneity between studies.The combined application of CD64 and CRP improved the accuracy of neonatal sepsis diagnosis.Copyright © 2019. Published by Elsevier Inc.

2019 EvidenceUpdates

16. Assessing Fluid Resuscitation in Adults with Sepsis Who Are Not Mechanically Ventilated: a Systematic Review of Diagnostic Test Accuracy Studies Full Text available with Trip Pro

Assessing Fluid Resuscitation in Adults with Sepsis Who Are Not Mechanically Ventilated: a Systematic Review of Diagnostic Test Accuracy Studies Fluid resuscitation is a widely used intervention that is mandated in the management of sepsis. While its use can be life-saving, its overuse is associated with harm. Despite this, the best means of assessing a need for fluid resuscitation in an acute medical setting is unclear.To assess studies of diagnostic tests that identify the need for fluid (...) resuscitation in adults with sepsis, as defined by the presence of fluid responsiveness.Protocol registration was performed in advance (PROSPERO:CRD42017048651). Research database searches were performed alongside additional searches to identify grey literature. Diagnostic test accuracy studies that assessed any fluid assessment tool were identified independently by two authors, before data extraction and quality assessments were performed.Adults with sepsis, without intensive care organ support, who would

2019 EvidenceUpdates

17. Hypertonic Saline in Human Sepsis: A Systematic Review of Randomized Controlled Trials (Abstract)

Hypertonic Saline in Human Sepsis: A Systematic Review of Randomized Controlled Trials The role of hypertonic saline in sepsis remains unclear because clinical data are limited and the balance between beneficial and adverse effects is not well defined. In this systematic literature review, we searched PubMed and Embase to identify all randomized controlled trials up until January 31, 2018 in which hypertonic saline solutions of any concentration were used in patients of all ages with sepsis (...) effects on renal function (moderate-quality evidence). Some data suggested a beneficial effect of hypertonic saline solutions on some hemodynamic parameters and the immunomodulatory profile (very low-quality evidence). Mortality rates were not significantly different with hypertonic saline than with other fluids (odds ratio, 0.946; 95% CI, 0.688-1.301; P = .733; low-quality evidence). In conclusion, in our meta-analysis of studies in patients with sepsis, hypertonic saline reduced the volume of fluid

2019 EvidenceUpdates

18. Does the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Improve Survival in Septic Adults? Full Text available with Trip Pro

Does the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Improve Survival in Septic Adults? Does the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Improve Survival in Septic Adults? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 73, Issue 4, Pages 363–365 Does the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Improve Survival in Septic Adults? x (...) all Collapse all Article Outline Take-Home Message No high- or moderate-level evidence shows that the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) hemodynamic interventions improve survival in sepsis. Methods Data Sources The authors searched PubMed, EMBASE, Scopus, Web of Science, and without language restrictions from inception to November 28, 2017. They also searched the references of analyzed studies and other review articles. Study Selection Investigators included randomized

2019 Annals of Emergency Medicine Systematic Review Snapshots

19. Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial. Full Text available with Trip Pro

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial. Previous research suggested that soluble human recombinant thrombomodulin may reduce mortality among patients with sepsis-associated coagulopathy.To determine the effect of human recombinant thrombomodulin vs placebo on 28-day all-cause mortality among patients with sepsis-associated coagulopathy.The SCARLET trial was a randomized, double (...) -blind, placebo-controlled, multinational, multicenter phase 3 study conducted in intensive care units at 159 sites in 26 countries. All adult patients admitted to one of the participating intensive care units between October 2012 and March 2018 with sepsis-associated coagulopathy and concomitant cardiovascular and/or respiratory failure, defined as an international normalized ratio greater than 1.40 without other known etiology and a platelet count in the range of 30 to 150 × 109/L or a greater than

2019 JAMA Controlled trial quality: predicted high

20. Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis. Full Text available with Trip Pro

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis. Sepsis is a heterogeneous syndrome. Identification of distinct clinical phenotypes may allow more precise therapy and improve care.To derive sepsis phenotypes from clinical data, determine their reproducibility and correlation with host-response biomarkers and clinical outcomes, and assess the potential causal relationship with results from randomized clinical trials (RCTs).Retrospective (...) analysis of data sets using statistical, machine learning, and simulation tools. Phenotypes were derived among 20 189 total patients (16 552 unique patients) who met Sepsis-3 criteria within 6 hours of hospital presentation at 12 Pennsylvania hospitals (2010-2012) using consensus k means clustering applied to 29 variables. Reproducibility and correlation with biological parameters and clinical outcomes were assessed in a second database (2013-2014; n = 43 086 total patients and n = 31 160 unique

2019 JAMA