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2. Effect of a Long Bout Versus Short Bouts of Walking on Weight Loss During a Weight-Loss Diet: A Randomized Trial

Effect of a Long Bout Versus Short Bouts of Walking on Weight Loss During a Weight-Loss Diet: A Randomized Trial This study aimed to evaluate the effect of different daily physical activity (PA) frequencies, while maintaining the same daily volume of PA, on weight loss, carbohydrate metabolism, and lipid metabolism in women with overweight or obesity throughout a 24-week intervention.During their weight-loss plan, 65 women (BMI = 27-35 kg/m2 ; age = 18-40 years) who had a sedentary lifestyle (...) were randomly allocated to the following groups: diet plus a long bout of moderate physical activity (LBP) (one 50-minute bout of moderate-intensity PA) 6 d/wk or diet plus short bouts of moderate physical activity (SBP) (two 25-minute bouts of moderate-intensity PA) 6 d/wk. Anthropometric and blood measurements were taken at baseline and at 24 weeks.Compared with the LBP group, the SBP group had a greater decrease in weight (SBP: -8.08 ± 2.20 kg; LBP: -6.39 ± 2.28 kg; P = 0.019), BMI (SBP: -3.11

2019 EvidenceUpdates

3. Diet vs. Exercise: which is superior for weight loss?

Diet vs. Exercise: which is superior for weight loss? Diet vs. Exercise: Which Is Superior for Weight Loss? – Clinical Correlations Search Diet vs. Exercise: Which Is Superior for Weight Loss? November 9, 2018 4 min read By Kurtis Carlock, MD Peer Reviewed Obesity is a problem that affects over one-third of adults in the US and increases s. [1] The question of how best to combat obesity is a problem that has interested physicians and scientists since it was first recognized as a major health (...) expenditure (calories burned by movement and exercise), and diet-induced thermogenesis (energy consumed as part of food processing). 2 In most people, diet-induced thermogenesis accounts for 8-15% of TEE, while resting energy expenditure is more variable and accounts for the majority (50-75%) of TEE. Activity energy expenditure . [2,3] The theory behind diet or exercise as a tool for weight loss is simple: either decrease the energy intake or increase the activity energy expenditure to a point where total

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2018 Clinical Correlations

4. Less Pancakes, More Bacon? The Ketogenic Diet for Weight Loss

Less Pancakes, More Bacon? The Ketogenic Diet for Weight Loss Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,800 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca (...) September 24, 2018 Less Pancakes, More Bacon? The Ketogenic Diet for Weight Loss Clinical Question: Is the ketogenic diet effective for weight loss? Bottom Line: At best, ketogenic diets help patients lose ~2 kg more than low-fat diets at one year, but higher quality studies show no difference. Weight loss peaks ~5 months but is generally not sustained. There are no randomized controlled trials (RCTs) on mortality or cardiovascular disease. An individual’s weight change can vary -30 to +10 kg with any

2018 Tools for Practice

5. Effect of a Long Bout Versus Short Bouts of Walking on Weight Loss During a Weight-Loss Diet: A Randomized Trial. (PubMed)

Effect of a Long Bout Versus Short Bouts of Walking on Weight Loss During a Weight-Loss Diet: A Randomized Trial. This study aimed to evaluate the effect of different daily physical activity (PA) frequencies, while maintaining the same daily volume of PA, on weight loss, carbohydrate metabolism, and lipid metabolism in women with overweight or obesity throughout a 24-week intervention.During their weight-loss plan, 65 women (BMI = 27-35 kg/m2 ; age = 18-40 years) who had a sedentary lifestyle (...) were randomly allocated to the following groups: diet plus a long bout of moderate physical activity (LBP) (one 50-minute bout of moderate-intensity PA) 6 d/wk or diet plus short bouts of moderate physical activity (SBP) (two 25-minute bouts of moderate-intensity PA) 6 d/wk. Anthropometric and blood measurements were taken at baseline and at 24 weeks.Compared with the LBP group, the SBP group had a greater decrease in weight (SBP: -8.08 ± 2.20 kg; LBP: -6.39 ± 2.28 kg; P = 0.019), BMI (SBP: -3.11

2019 Obesity Controlled trial quality: uncertain

6. Group-based diet and exercise programmes can lead to weight loss

Group-based diet and exercise programmes can lead to weight loss Weight loss may occur through group-based diet and exercise programmes Discover Portal Discover Portal Group-based diet and exercise programmes can lead to weight loss Published on 26 June 2018 doi: The evidence is growing that group-based weight loss programmes can offer effective and acceptable options for overweight people, particularly men. On average, people in group dietary advice and exercise programmes lose 3.5kg more than (...) [CI] -4.2 to ‑2.8), 3.4 kg at 12 months (95% CI -4.2 to -2.9), and 2.6 kg at 24 months (95% CI -3.8 to -1.3). Explicitly targeting weight loss and including feedback and diet goals/plans were significantly associated with intervention effectiveness. Group-based interventions delivered to men only were on average twice as effective as those to women only (average weight 5.5 vs 2.6 kg). Mean attendance was 67%, as reported for 41 interventions (range 21–87%). What does current guidance say

2019 NIHR Dissemination Centre

7. Low fat or low carbohydrate diets seem just as effective for weight loss

Low fat or low carbohydrate diets seem just as effective for weight loss Low fat or low carbohydrate diets seem just as effective for weight loss Discover Portal Discover Portal Low fat or low carbohydrate diets seem just as effective for weight loss Published on 22 May 2018 doi: Overweight to obese adults who followed a low fat or low carbohydrate diet for 12 months both lost around 5 or 6kg in body weight. It made no difference whether they had a gene-type indicating that they break down fats (...) or carbohydrates better. Obesity is a major public health concern and there are many weight-loss approaches and fad diets that people try. Dietary trials tend to observe only modest weight loss. Given wide population variation, some suggest that knowing the genetic or metabolic characteristics of individuals might determine which diet is better for whom. This US trial including 600 adults who followed strict dietary interventions found no evidence for this. The time to weight loss and range of loss among

2019 NIHR Dissemination Centre

8. The association between weight maintenance and session-by-session diet adherence, weight loss and weight-loss satisfaction. (PubMed)

The association between weight maintenance and session-by-session diet adherence, weight loss and weight-loss satisfaction. The aim of this study was to assess the association between weight-loss maintenance and weight-loss satisfaction, adherence to diet and weight loss, all measured session-by-session during the weight-loss phase of cognitive behavioral therapy.The present exploratory study examined a subgroup of fifty-eight patients who participated in a randomized controlled trial and who (...) lost at least the 10% of their baseline weight. Patients were grouped into weight-loss 'Maintainers' (i.e., those who maintained a weight loss of ≥ 10% of baseline body weight at 6 months after the weight-loss phase) and 'Regainers' (i.e., those who did not maintain > 10% weight loss at 6 months after the weight-loss phase). Body weight, adherence to diet and weight-loss satisfaction were measured session-by-session during the weight-loss phase.Thirteen patients (22.4%) were classified

2018 Eating and weight disorders : EWD Controlled trial quality: uncertain

9. Changes in blood lipid concentrations associated with changes in intake of dietary saturated fat in the context of a healthy low-carbohydrate weight-loss diet: a secondary analysis of the Diet Intervention Examining The Factors Interacting with Treatment (PubMed)

Changes in blood lipid concentrations associated with changes in intake of dietary saturated fat in the context of a healthy low-carbohydrate weight-loss diet: a secondary analysis of the Diet Intervention Examining The Factors Interacting with Treatment For low-carbohydrate diets, a public health approach has focused on the replacement of carbohydrates with unsaturated fats. However, little research exists on the impacts of saturated fat intake on the lipid profile in the context of whole-food (...) -based low-carbohydrate weight-loss diets.The primary aim of this secondary analysis of the DIETFITS weight loss trial was to evaluate the associations between changes in percentage of dietary saturated fatty acid intake (%SFA) and changes in low-density lipoproteins, high-density lipoproteins, and triglyceride concentrations for those following a healthy low-carbohydrate (HLC) diet. The secondary aim was to examine these associations specifically for HLC dieters who had the highest 12-month

2019 American Journal of Clinical Nutrition Controlled trial quality: uncertain

10. Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial. (PubMed)

Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial. Adiposity and the gut microbiota are both related to the risk of type 2 diabetes. We aimed to comprehensively examine how changes induced by a weight-loss diet intervention in gut microbiota-related metabolites, such as trimethylamine N-oxide (TMAO) and its precursors (choline and l-carnitine), were associated with improvements in adiposity and regional fat (...) with increases in choline or l-carnitine were 2.35-times (95% CI 1.38, 4.00) or 1.77-times (1.06, 2.95) more likely to fail to lose weight (-5% or more loss) at 2 years.Overweight and obese individuals who showed decreases in circulating choline or l-carnitine levels achieved greater improvements of adiposity and energy metabolism by eating a low-calorie weight-loss diet, suggesting that such metabolites are predictive of individuals' response to the treatment. Further investigations are necessary to confirm

2018 Diabetes Care Controlled trial quality: uncertain

11. Alignment of diet prescription to genotype does not promote greater weight loss success in women with obesity participating in an exercise and weight loss program. (PubMed)

Alignment of diet prescription to genotype does not promote greater weight loss success in women with obesity participating in an exercise and weight loss program. Genetics contribute to variability in individual response to weight-loss interventions. The objective of this study was to determine the efficacy of a commercially available exercise and weight-loss program and whether alignment of diet to genotype related to lipid metabolism promotes greater success.Sedentary women with obesity (n (...)  = 63) had genotype (FABP2rs1799883, PPARG2rs1801282, ADRB3rs4994C3, ADRB2rs1042713, rs1042714) determined using a direct-to-consumer genetic screening kit purported to promote greater weight-loss success through dietary recommendations based on these genes. Participants were randomly assigned to follow a moderate carbohydrate (MC) or lower carbohydrate (LC) hypo-energetic diet that aligned (A) or did not align (NA) with genotype for 24 weeks while participating in a resistance training and walking

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2018 Obesity science & practice Controlled trial quality: uncertain

12. Withaferin A inhibits adipogenesis in 3T3-F442A cell line, improves insulin sensitivity and promotes weight loss in high fat diet-induced obese mice. (PubMed)

Withaferin A inhibits adipogenesis in 3T3-F442A cell line, improves insulin sensitivity and promotes weight loss in high fat diet-induced obese mice. The increased prevalence of obesity and associated insulin resistance calls for effective therapeutic treatment of metabolic diseases. The current PPARγ-targeting antidiabetic drugs have undesirable side effects. The present study investigated the anti-diabetic and anti-obesity effects of withaferin A (WFA) in diet-induced obese (DIO) C57BL/6J (...) of WFA was evaluated in 3T3- F442A cell line. WFA treatment prevented weight gain without affecting food or caloric intake in DIO mice. WFA-treated group also exhibited lower epididymal and mesenteric fat pad mass, an improvement in lipid profile and hepatic steatosis and a reduction in serum inflammatory cytokines. Insulin resistance was reduced as shown by an improvement in glucose and insulin tolerance and serum adiponectin. WFA treatment upregulated selective insulin signaling (insr, irs1, slc2a4

2019 PLoS ONE

13. Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial. (PubMed)

Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial. To determine the effects of diets varying in carbohydrate to fat ratio on total energy expenditure.Randomized trial.Multicenter collaboration at US two sites, August 2014 to May 2017.164 adults aged 18-65 years with a body mass index of 25 or more.After 12% (within 2%) weight loss on a run-in diet, participants were randomly assigned to one of three test diets according to carbohydrate (...) content (high, 60%, n=54; moderate, 40%, n=53; or low, 20%, n=57) for 20 weeks. Test diets were controlled for protein and were energy adjusted to maintain weight loss within 2 kg. To test for effect modification predicted by the carbohydrate-insulin model, the sample was divided into thirds of pre-weight loss insulin secretion (insulin concentration 30 minutes after oral glucose).The primary outcome was total energy expenditure, measured with doubly labeled water, by intention-to-treat analysis. Per

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2018 BMJ Controlled trial quality: predicted high

14. Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial. (PubMed)

Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial. Dietary modification remains key to successful weight loss. Yet, no one dietary strategy is consistently superior to others for the general population. Previous research suggests genotype or insulin-glucose dynamics may modify the effects of diets.To determine the effect of a healthy low-fat (HLF) diet vs (...) weight loss. There were 18 adverse events or serious adverse events that were evenly distributed across the 2 diet groups.In this 12-month weight loss diet study, there was no significant difference in weight change between a healthy low-fat diet vs a healthy low-carbohydrate diet, and neither genotype pattern nor baseline insulin secretion was associated with the dietary effects on weight loss. In the context of these 2 common weight loss diet approaches, neither of the 2 hypothesized predisposing

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2018 JAMA Controlled trial quality: predicted high

15. Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial

Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial The long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body weight and cardiovascular risk factors in PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a trial designed to evaluate the long-term effectiveness of an intensive weight-loss (...) lifestyle intervention on primary cardiovascular prevention.Overweight/obese adults with metabolic syndrome aged 55-75 years (n = 626) were randomized to an intensive weight-loss lifestyle intervention based on an energy-restricted Mediterranean diet, physical activity promotion, and behavioral support (IG) or a control group (CG). The primary and secondary outcomes were changes in weight and cardiovascular risk markers, respectively.Diet and physical activity changes were in the expected direction

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2018 EvidenceUpdates

16. A Randomized Trial of Lorcaserin and Lifestyle Counseling for Maintaining Weight Loss Achieved with a Low-Calorie Diet

A Randomized Trial of Lorcaserin and Lifestyle Counseling for Maintaining Weight Loss Achieved with a Low-Calorie Diet Improving the maintenance of lost weight remains a critical challenge, which can be addressed by long-term behavioral and/or pharmacological interventions.This study investigated the efficacy of combined behavioral and pharmacological treatment in facilitating weight loss maintenance (WLM) in 137 adults (86.1% female; 68.6% black; BMI = 37.0 ± 5.6 kg/m2 ) who had lost ≥ 5 (...) % of initial weight during a 14-week low-calorie diet (LCD) program (mean = 9.3 ± 2.9%). Participants were randomly assigned to lorcaserin (10 mg twice a day) or placebo and were provided 16 group WLM counseling sessions over 52 weeks.At 24 weeks post randomization, more lorcaserin-treated than placebo-treated participants maintained a ≥ 5% loss (73.9% vs. 57.4%; P = 0.033), and the lorcaserin-treated participants lost an additional 2.4 ± 0.8 kg versus a 0.6 ± 0.8 kg gain for placebo (P = 0.010). However

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2018 EvidenceUpdates

17. Very-low-carbohydrate ketogenic diet v low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials

Very-low-carbohydrate ketogenic diet v low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials Very-low-carbohydrate ketogenic diet v low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials Very-low-carbohydrate ketogenic diet v low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials Bueno NB, de Melo IS, de Oliveira SL, da Rocha Ataide T CRD summary This review concluded that individuals assigned (...) to a very-low-carbohydrate ketogenic diet achieved greater long-term reductions in body weight and certain blood cardiovascular risk factors than those assigned to a low fat diet. The conclusions of this well-conducted systematic review are likely to be reliable but the magnitude of the results were of little clinical significance. Authors' objectives To compare a very-low-carbohydrate ketogenic diet with a low fat diet in overweight and obese individuals, in terms of long-term weight loss. Searching

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2013 DARE.

18. Are app-based lifestyle interventions (diet, exercise and psychology) effective for weight loss in overweight adults? A systematic review

Are app-based lifestyle interventions (diet, exercise and psychology) effective for weight loss in overweight adults? A systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration (...) software. In case data are not reported or unclear, we will attempt to contact authors by e-mail (max. 2 attempts). In case an outcome is measured at multiple time points, data from the time point where efficacy is highest will be included. ">Methods for data extraction Example: Experimental groups, control group(s) and number of animals per group. ">Data to be extracted: study design Example: Species, sex, weight, age, co‐morbidity, anaesthetic agent used, method of induction of cardiac ischemia

2019 PROSPERO

19. Systematic review of intervention studies on gene-diet-interactions on weight loss

Systematic review of intervention studies on gene-diet-interactions on weight loss Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email (...) will attempt to contact authors by e-mail (max. 2 attempts). In case an outcome is measured at multiple time points, data from the time point where efficacy is highest will be included. ">Methods for data extraction Example: Experimental groups, control group(s) and number of animals per group. ">Data to be extracted: study design Example: Species, sex, weight, age, co‐morbidity, anaesthetic agent used, method of induction of cardiac ischemia, duration of ischemia and duration of reperfusion (if applicable

2019 PROSPERO

20. Weight loss surgery for obesity can lead to substantial weight loss and improved health outcomes

Weight loss surgery for obesity can lead to substantial weight loss and improved health outcomes Weight loss surgery for obesity can lead to substantial weight loss and improved health outcomes Discover Portal Discover Portal Weight loss surgery for obesity can lead to substantial weight loss and improved health outcomes Published on 9 February 2016 doi: On average people lost 5 kg more in each of the first four months after weight loss surgery than those of a similar weight who did not undergo (...) the number of people with obesity-related health conditions after surgery would give economic benefits alongside the health benefits to the individual. This study provides a compelling clinical case for weight loss surgery for appropriately selected people. Share your views on the research. Why was this study needed? Around 13 million people, a quarter of the UK adult population, is currently obese (with a BMI of 30 kg/m2 or more), and over a million of those are morbidly obese (BMI more 40 kg/m2 or more

2018 NIHR Dissemination Centre

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