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1. Neon EEG electrode for EEG monitoring in newborns

Neon EEG electrode for EEG monitoring in newborns Neon EEG electrode for EEG monitoring in Neon EEG electrode for EEG monitoring in newborns newborns Medtech innovation briefing Published: 24 August 2018 nice.org.uk/guidance/mib155 pathways Summary Summary The technology technology described in this briefing is Neon EEG electrode. It is used for electroencephalogram (EEG) monitoring in newborns. The inno innovativ vative aspects e aspects are that EEG electrodes can be placed on a newborn (...) , without extra preparation or an EEG technician. The intended place in ther place in therap apy y would be in the neonatal intensive care unit in newborns with suspected perinatal brain injury. There is no published e no published evidence vidence for this device. K Ke ey uncertainties y uncertainties around the evidence or technology are that there are no published studies showing the accuracy, ease of use or reliability of the device. The cost cost of the Neon EEG is £50 to £60 per unit (exclusive

2018 National Institute for Health and Clinical Excellence - Advice

2. Premature newborn care

Premature newborn care Premature newborn care - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Premature newborn care Last reviewed: February 2019 Last updated: February 2019 Summary A premature infant is an infant born before 37 weeks' gestation. In addition to immediate post-birth resuscitation, efforts to reduce excessive oxygen exposure, hyperventilation, hypothermia, and hypoglycaemia must be made. Consultation (...) with a neonatologist as soon as possible is recommended to provide expertise to reduce potential morbidity. Gestational age determination done within hours of birth is important for designating further care of the premature newborn. The risk of adverse outcomes varies inversely with gestational age. The New Ballard Score uses measurements of neuromuscular and physical maturity to complement the maternal history and ultrasonographic findings to estimate gestational age, although a first-trimester ultrasound remains

2019 BMJ Best Practice

3. Needle aspiration versus intercostal tube drainage for pneumothorax in the newborn. Full Text available with Trip Pro

Needle aspiration versus intercostal tube drainage for pneumothorax in the newborn. Pneumothorax occurs more frequently in the neonatal period than at any other time of life and is associated with increased mortality and morbidity. It can be treated with either aspiration with a syringe (using a needle or an angiocatheter) or a chest tube inserted in the anterior pleural space and then connected to a Heimlich valve or an underwater seal with continuous suction.To compare the efficacy and safety (...) , and the reference lists of retrieved articles for randomised controlled trials and quasi-randomised trials.Randomised controlled trials, quasi-randomised controlled trials and cluster trials comparing needle aspiration (either with the needle or angiocatheter left in situ or removed immediately after aspiration) to intercostal tube drainage in newborn infants with pneumothorax.For each of the included trials, two authors independently extracted data (e.g. number of participants, birth weight, gestational age

2019 Cochrane

4. C-reactive protein for diagnosing late-onset infection in newborn infants. Full Text available with Trip Pro

C-reactive protein for diagnosing late-onset infection in newborn infants. Late-onset infection is the most common serious complication associated with hospital care for newborn infants. Because confirming the diagnosis by microbiological culture typically takes 24 to 48 hours, the serum level of the inflammatory marker C-reactive protein (CRP) measured as part of the initial investigation is used as an adjunctive rapid test to guide management in infants with suspected late-onset infection.To (...) determine the diagnostic accuracy of serum CRP measurement in detecting late-onset infection in newborn infants.We searched electronic databases (MEDLINE, Embase, and Science Citation Index to September 2017), conference proceedings, previous reviews, and the reference lists of retrieved articles.We included cohort and cross-sectional studies evaluating the diagnostic accuracy of serum CRP levels for the detection of late-onset infection (occurring more than 72 hours after birth) in newborn infants.Two

2019 Cochrane

5. Pharmacological interventions for prevention and treatment of upper gastrointestinal bleeding in newborn infants. (Abstract)

Pharmacological interventions for prevention and treatment of upper gastrointestinal bleeding in newborn infants. Upper gastrointestinal bleeding is typically a mild, self-limiting condition that can affect both preterm and term neonates, although it can be severe particularly when associated with co-morbidities. Pharmacological interventions with a proton pump inhibitor (PPI), H2 receptor antagonist (H2RA), antacid, bismuth and sucralfate may have effects on both the prevention and treatment (...) antagonist for prevention of upper gastrointestinal bleeding in high-risk newborn infants. Meta-analysis of these four trials identified a reduction in any upper gastrointestinal bleeding when using an H2 receptor antagonist (typical risk ratio (RR) 0.36, 95% confidence interval (CI) 0.22 to 0.58; typical risk difference (RD) -0.20, 95% CI -0.28 to -0.11; number needed to treat for an additional beneficial outcome (NNTB) 5, 95% CI 4 to 9). The quality of evidence was moderate. A single trial with 53

2019 Cochrane

6. Antibiotic treatment for newborns with congenital syphilis. (Abstract)

Antibiotic treatment for newborns with congenital syphilis. Congenital syphilis continues to be a substantial public health problem in many parts of the world. Since the first use of penicillin for the treatment of syphilis in 1943, which was a notable early success, it has remained the preferred and standard treatment including for congenital syphilis. However, the treatment of congenital syphilis is largely based on clinical experience and there is extremely limited evidence on the optimal (...) dose or duration of administration of penicillin or the use of other antibiotics.To assess the effectiveness and safety of antibiotic treatment for newborns with confirmed, highly probable and possible congenital syphilis.We searched the Cochrane STI Group Specialized Register, CENTRAL, MEDLINE, Embase, LILACS, WHO ICTRP, ClinicalTrials.gov and Web of Science to 23 May 2018. We also handsearched conference proceedings, contacted trial authors and reviewed the reference lists of retrieved

2019 Cochrane

7. Newborn screening for sickle cell disease

Newborn screening for sickle cell disease 1 Translation of Chapters 1 to 6 of the final report S18-01 Screening auf Sichelzellkrankheit (SCD) bei Neugeborenen (Version 1.0; Status: 25 July 2019 [German original], 28 November 2019 [English translation]). Please note: This document was translated by an external translator and is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. Extract IQWiG (...) Reports – Commission No. S18-01 Newborn screening for sickle cell disease (SCD) 1 Extract of final report S18-01 Version 1.0 Newborn screening for sickle cell disease (SCD) 25 July 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Newborn screening for sickle cell disease (SCD) Commissioning agency: Federal Joint Committee Commission awarded on: 28 June 2018 Internal Commission No.: S18-01

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

8. Newborn hearing screening programme (NHSP) operational guidance

Newborn hearing screening programme (NHSP) operational guidance Newborn hearing screening programme (NHSP) operational guidance - GOV.UK GOV.UK uses cookies to make the site simpler. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Newborn hearing screening programme (NHSP) operational guidance This guidance supports healthcare professionals and stakeholders delivering and managing newborn hearing screening programmes in England. Published 1 November 2016 (...) Last updated 16 July 2019 — From: Documents HTML HTML HTML HTML HTML HTML HTML HTML HTML HTML HTML https://www.gov.uk/government/publications/newborn-hearing-screening-equipment-log-sheets If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email . Please tell us what format you need. It will help us if you say what assistive technology you use. MS Word Document , 23.9KB This file may not be suitable for users

2019 Public Health England

9. Newborn and infant physical examination: programme handbook

Newborn and infant physical examination: programme handbook Newborn and infant physical examination: programme handbook - GOV.UK GOV.UK uses cookies to make the site simpler. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search The United Kingdom is leaving the European Union on 31 October 2019. Guidance Newborn and infant physical examination: programme handbook This document brings together all the guidelines that relate to the NHS newborn and infant physical (...) ) and need a version of this document in a more accessible format, please email . Please tell us what format you need. It will help us if you say what assistive technology you use. Details The purpose of this handbook is to inform and support best clinical practice in the NHS newborn and infant physical examination ( 27 August 2019 Updated NIPE programme handbook. 24 April 2018 Updated pathway appendices in accessible PDF formats. 19 April 2018 Minor correction to neonatal hip risk factors under Standard

2019 Public Health England

10. The screening and management of newborns at risk for low blood glucose

The screening and management of newborns at risk for low blood glucose Hypoglycemia in the first hours to days after birth remains one of the most common conditions facing practitioners across Canada who care for newborns. Many cases represent normal physiologic transition to extrauterine life, but another group experiences hypoglycemia of longer duration. This statement addresses key issues for providers of neonatal care, including the definition of hypoglycemia, risk factors, screening (...) approaches to care for hypoglycemia during the ‘transitional’ phase—the first 72 hours post-birth—and persistent hypoglycemia, which occurs or presents for the first time past that point. Keywords: Dextrose gel; Hypoglycemia; Newborn; Point-of-care

2019 Canadian Paediatric Society

11. Maternal and Newborn Survival in Sub-Saharan Africa

Maternal and Newborn Survival in Sub-Saharan Africa From minding the gap to closing the gap Science to transform maternal and newborn survival and stillbirths in sub-Saharan Africa in the Sustainable Development Goals era Workshop report 4–5 September 2018. Nairobi, Kenya.The Academy of Medical Sciences is the independent body in the UK representing the diversity of medical science. Our mission is to promote medical science and its translation into benefits for society. The Academy’s elected (...) ’ highly prestigious fellowship and award schemes, providing advisory and think tank functions for shaping Africa’s Science, Technology and Innovation (STI) strategies and policies and implementing key Science, Technology and Innovation (STI) programmes addressing Africa’s developmental challenges.Contents Executive summary 4 Status of maternal and newborn health in Africa 8 Grand Challenge 1: Better careduring pregnancy 10 Grand Challenge 2: Better care at birth 14 Grand Challenge 3: Better postnatal

2019 Academy of Medical Sciences

12. Sickle cell and thalassaemia screening: newborn outcomes system

Sickle cell and thalassaemia screening: newborn outcomes system SCT newborn outcomes system: overview - GOV.UK GOV.UK uses cookies to make the site simpler. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance SCT newborn outcomes system: overview Published 19 March 2019 Contents © Crown copyright 2019 This publication is licensed under the terms of the Open Government Licence v3.0 except where otherwise stated. To view this licence, visit or write (...) to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: . Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. This publication is available at https://www.gov.uk/government/publications/sickle-cell-and-thalassaemia-screening-newborn-outcomes-system/sct-newborn-outcomes-system-overview System overview The sickle cell and thalassaemia ( . team in Public Health England ( ( Is this page useful? Thank you

2019 Public Health England

13. Prevention of Early-Onset Group B Streptococcal Disease in Newborns

Prevention of Early-Onset Group B Streptococcal Disease in Newborns INTERIM UPDATE ACOGCOMMITTEEOPINION Number 797 (Replaces Committee Opinion No. 782, June 2019) Committee on Obstetric Practice The American Academy of Pediatrics, the American College of Nurse-Midwives, the Association of Women’s Health, Obstetric and Neonatal Nurses, and the Society for Maternal-Fetal Medicine endorse this document. Although the American Society for Microbiology cannot endorse this document because the content (...) in this Committee Opinion has been updated as highlighted (or removed as necessary) to reflect a limited, focused change in the language regarding penicillin allergy testing, categories for penicillin (ie, low- risk and high-risk of anaphylaxis or severe reaction) (Table 2), and penicillin dose (Figure 3). Prevention of Group B Streptococcal Early-Onset Disease in Newborns ABSTRACT: Group B streptococcus (GBS) is the leading cause of newborn infection. The primary risk factor forneonatalGBSearly-onsetdisease

2020 American College of Obstetricians and Gynecologists

14. Guidelines for vitamin K prophylaxis in newborns

Guidelines for vitamin K prophylaxis in newborns Newborns are at risk for vitamin K deficiency bleeding (VKDB) caused by inadequate prenatal storage and deficiency of vitamin K in breast milk. Systematic review of evidence to date suggests that a single intramuscular (IM) injection of vitamin K at birth effectively prevents VKDB. Current scientific data suggest that single or repeated doses of oral (PO) vitamin K are less effective than IM vitamin K in preventing VKDB. The Canadian Paediatric (...) Society and the College of Family Physicians of Canada recommend routine IM administration of a single dose of vitamin K at 0.5 mg to 1.0 mg to all newborns. Administering PO vitamin K (2.0 mg at birth, repeated at 2 to 4 and 6 to 8 weeks of age), should be confined to newborns whose parents decline IM vitamin K. Health care providers should clarify with parents that newborns are at increased risk of VKDB if such a regimen is chosen. Current evidence is insufficient to recommend routine intravenous

2018 CPG Infobase

15. Premature newborn care

Premature newborn care Premature newborn care - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Premature newborn care Last reviewed: February 2019 Last updated: February 2019 Summary A premature infant is an infant born before 37 weeks' gestation. In addition to immediate post-birth resuscitation, efforts to reduce excessive oxygen exposure, hyperventilation, hypothermia, and hypoglycaemia must be made. Consultation (...) with a neonatologist as soon as possible is recommended to provide expertise to reduce potential morbidity. Gestational age determination done within hours of birth is important for designating further care of the premature newborn. The risk of adverse outcomes varies inversely with gestational age. The New Ballard Score uses measurements of neuromuscular and physical maturity to complement the maternal history and ultrasonographic findings to estimate gestational age, although a first-trimester ultrasound remains

2018 BMJ Best Practice

16. Assessment of cyanosis in the newborn

Assessment of cyanosis in the newborn Assessment of cyanosis in the newborn - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of cyanosis in the newborn Last reviewed: February 2019 Last updated: November 2018 Summary Tachypnoea and cyanosis are frequently encountered in the neonatal period. The prevalence of respiratory distress in newborns ranges from 2.9% to 7.6%. Cyanosis can result from a range (...) of disorders, including cardiac, metabolic, neurological, and pulmonary disorders. In all, 4.3% of newborns may require supplemental oxygen therapy because of cyanosis. Hjalmarson O. Epidemiology and classification of acute neonatal respiratory disorders: a prospective study. Acta Paediatr Scand. 1981 Nov;70(6):773-83. http://www.ncbi.nlm.nih.gov/pubmed/7324931?tool=bestpractice.com Hjalmarson O. Epidemiology of neonatal disorders of respiration. Int J Technol Assess Health Care. 1991;7 Suppl 1:9-15. http

2018 BMJ Best Practice

17. Assessment of cyanosis in the newborn

Assessment of cyanosis in the newborn Assessment of cyanosis in the newborn - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of cyanosis in the newborn Last reviewed: February 2019 Last updated: November 2018 Summary Tachypnoea and cyanosis are frequently encountered in the neonatal period. The prevalence of respiratory distress in newborns ranges from 2.9% to 7.6%. Cyanosis can result from a range (...) of disorders, including cardiac, metabolic, neurological, and pulmonary disorders. In all, 4.3% of newborns may require supplemental oxygen therapy because of cyanosis. Hjalmarson O. Epidemiology and classification of acute neonatal respiratory disorders: a prospective study. Acta Paediatr Scand. 1981 Nov;70(6):773-83. http://www.ncbi.nlm.nih.gov/pubmed/7324931?tool=bestpractice.com Hjalmarson O. Epidemiology of neonatal disorders of respiration. Int J Technol Assess Health Care. 1991;7 Suppl 1:9-15. http

2018 BMJ Best Practice

18. Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants. Full Text available with Trip Pro

Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants. Duration of use may be a modifiable risk factor for central venous catheter-associated bloodstream infection in newborn infants. Early planned removal of peripherally inserted central catheters (PICCs) is recommended as a strategy to reduce the incidence of infection and its associated morbidity and mortality.To determine the effectiveness of early planned (...) removal of PICCs (up to two weeks after insertion) compared to an expectant approach or a longer fixed duration in preventing bloodstream infection and other complications in newborn infants.We searched of the Cochrane Central Register of Controlled Trials (CENTRAL; 2018, Issue 4), Ovid MEDLINE, Embase, Maternity & Infant Care Database, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) (until April 2018), and conference proceedings and previous reviews.Randomised and quasi

2018 Cochrane

19. Xenon as an adjuvant to therapeutic hypothermia in near-term and term newborns with hypoxic-ischaemic encephalopathy. Full Text available with Trip Pro

Xenon as an adjuvant to therapeutic hypothermia in near-term and term newborns with hypoxic-ischaemic encephalopathy. Hypoxic-ischaemic encephalopathy (HIE) is a serious birth complication affecting term and late preterm newborns. Although therapeutic hypothermia (cooling) has been shown to be an effective therapy for neonatal HIE, many cooled infants have poor long-term neurodevelopmental outcomes. In animal models of neonatal encephalopathy, inhaled xenon combined with cooling has been shown (...) to offer better neuroprotection than cooling alone.To determine the effects of xenon as an adjuvant to therapeutic hypothermia on mortality and neurodevelopmental morbidity, and to ascertain clinically important side effects of xenon plus therapeutic hypothermia in newborn infants with HIE. To assess early predictors of adverse outcomes and potential side effects of xenon.We used the standard strategy of the Cochrane Neonatal Review Group to search the Cochrane Library (2017, Issue 8), MEDLINE (from

2018 Cochrane

20. Naloxone for opioid-exposed newborn infants. Full Text available with Trip Pro

Naloxone for opioid-exposed newborn infants. Naloxone, a specific opioid antagonist, is available for the treatment of newborn infants with cardiorespiratory or neurological depression that may be due to intrauterine exposure to opioid. It is unclear whether newborn infants may benefit from this therapy and whether naloxone has any harmful effects.To determine the effect of naloxone on the need for and duration of neonatal unit stay in infants of mothers who received opioid analgesia prior (...) Clinical Trials Register. We checked the reference lists of relevant articles to identify further potentially relevant studies.Randomised controlled trials comparing the administration of naloxone versus placebo, or no drug, or another dose of naloxone to newborn infants with suspected or confirmed in utero exposure to opioid.We extracted data using the standard methods of Cochrane Neonatal with separate evaluation of trial quality and data extraction by two review authors and synthesis of data using

2018 Cochrane

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