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Four-year study of cobalt and chromium blood levels in patients managed with two different metal-on-metal total hip replacements.

Journal of Orthopaedic Research, 2003


Four-year study of cobalt and chromium blood levels in patients managed with two different metal-on-metal total hip replacements.
lhotka@telering.at BACKGROUND: Metal-on-metal total hip prostheses will produce a certain amount of wear debris.
METHODS: In 259 patients who with total hip replacement, blood cobalt and chromium concentrations were measured with atomic absorption spectrophotometry over a period of four years after arthroplasty.
Of the patients enrolled in the study, 131 had been managed with a METASUL cobalt-chromium alloy metal-on-metal bearing combination, while 128 had been given a SIKOMET-SM21 cobalt-chromium alloy metal-on-metal combination.
Cobalt concentrations were up to 50 times higher, while chromium concentrations were up to 100 times higher.
CONCLUSIONS: Both systems showed evidence, in the whole-blood samples, of wear debris production by the implants.
Therefore, patients managed with metal-on-metal bearing combinations should be carefully monitored in order to ensure that any local or systemic complications are detected early on.