Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development.

Breast, 2012

[Epub ahead of print] Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development.
Abstract Toll-like receptor (TLR) activation may be an important event in tumor cell immune evasion.
TLR2 and TLR4 gene polymorphisms have been related to increased susceptibility to cancer development in various organs.
261 patients and 480 health individuals were investigated for genotype and allelic frequencies of a 22-bp nucleotide deletion (-196 to -174del) in the promoter of TLR2 gene as well as two polymorphisms causing amino acid substitutions (Asp299Gly and Thr399Ile) in TLR4 gene.
As far as (-196 to -174del) in TLR2 gene is concerned ins/del and del/del genotypes and del allele were significantly more frequent in breast cancer patients compared to healthy controls.
Considering Asp299Gly replacement of TLR4 gene, Gly carriers (Asp/Gly & Gly/Gly genotype) and Gly allele were overrepresented among the breast cancer cases.
The -174 to -196del of TLR2 gene and Asp299Gly of TLR4 gene polymorphisms may confer an increased susceptibility to breast cancer development.
PMID: 22560646 [PubMed - as supplied by publisher] Full Text Sources
[Toll-like receptor gene polymorphisms and susceptibility to inflammatory bowel disease in Chinese Han and Caucasian populations].
Variant Toll-like receptor4 (Asp299Gly and Thr399Ile alleles) and Toll-like receptor2 (Arg753Gln and Arg677Trp alleles) in colorectal cancer.