Interventions for non-oliguric hyperkalaemia in preterm neonates

Cochrane Database of Systematic Reviews, 2011

Interventions for non‐oliguric hyperkalaemia in preterm neonates - The Cochrane Library - Vemgal - Wiley Online Library from LOGIN Enter e-mail address Enter password REMEMBER ME > > > > DATABASE TOOLS DATABASE MENU FIND ARTICLES OTHER RESOURCES Intervention Review You have full text access to this content Interventions for non‐oliguric hyperkalaemia in preterm neonates Prakash Vemgal 1,* , Arne Ohlsson 2 Editorial Group: Published Online: 16 MAY 2012 Assessed as up-to-date: 9 JUN 2011 DOI: 10.1002/14651858.CD005257.pub3 Copyright © 2012 The Cochrane Collaboration.
Publication History Publication Status: New search for studies and content updated (no change to conclusions) Published Online: 16 MAY 2012 SEARCH ARTICLE TOOLS Abstract Abstract Background Non-oliguric hyperkalaemia of the newborn is defined as a plasma potassium level > 6.5 mmol/L in the absence of acute renal failure.
Hyperkalaemia is a common complication in the first 48 hours of life in very low birth weight (VLBW) (birth weight < 1500 g) and/or very preterm newborns ( < 32 weeks gestational age).
Objectives To determine the effectiveness and safety of interventions for non-oliguric hyperkalaemia [for the purpose of this review defined as serum potassium > 6.0 mmol/L (the clinical setting in which interventions would likely be introduced prior to reaching a grossly abnormal level) and urine output > 0.5 ml/kg/hour] in preterm or VLBW infants during their first 72 hours of life.
Search methods The Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library , Issue 2, 2006) was searched to identify relevant randomised and quasi-randomised controlled trials.
The following data bases were searched in June 2006; MEDLINE from 1966, EMBASE from 1980, CINAHL from 1982.
Selection criteria Randomised or quasi-randomised controlled trials conducted in preterm and/or VLBW neonates with a diagnosis of non-oliguric hyperkalaemia.
Interventions included were those aimed at redistributing serum potassium (sodium bicarbonate or insulin and glucose) or increasing the elimination of potassium from the body [diuretics (any type) or ion exchange resins (any type), or exchange transfusion, or peritoneal dialysis, or salbutamol, or albuterol] or counteracting potential arrhythmias from hyperkalaemia (calcium) versus placebo or no intervention; or comparing any two of these interventions.
Data collection and analysis We used the standard review methods of the Cochrane Neonatal Review Group.
Two authors assessed all studies identified as potentially relevant by the literature search for inclusion in the review.
Statistical methods included relative risk (RR), risk difference (RD), number needed to treat to benefit (NNTB) or number needed to treat to harm (NNTH) for dichotomous and weighted mean difference (WMD) for continuous outcomes reported with 95% confidence intervals (CI).