Prophylactic antibiotics to reduce morbidity and mortality in newborn infants with intercostal catheters

Cochrane Database of Systematic Reviews, 2012

Prophylactic antibiotics to reduce morbidity and mortality in newborn infants with intercostal catheters - The Cochrane Library - Stewart - Wiley Online Library from LOGIN Enter e-mail address Enter password REMEMBER ME > > > > DATABASE TOOLS DATABASE MENU FIND ARTICLES OTHER RESOURCES Intervention Review You have full text access to this content Prophylactic antibiotics to reduce morbidity and mortality in newborn infants with intercostal catheters Alice Stewart 1,* , Garry DT Inglis 2 , Luke A Jardine 3 , Pieter Koorts 4 , Mark W Davies 2 Editorial Group: Published Online: 18 APR 2012 Assessed as up-to-date: 16 JUN 2011 DOI: 10.1002/14651858.CD008173.pub2 Copyright © 2012 The Cochrane Collaboration.
Prophylactic antibiotics to reduce morbidity and mortality in newborn infants with intercostal catheters.
Publication History Publication Status: New Published Online: 18 APR 2012 SEARCH ARTICLE TOOLS Abstract Abstract Background Intercostal catheters are commonly used for the drainage of intrathoracic collections in newborn infants, including pneumothorax and pleural effusions.
Placement of an intercostal drain is a potential risk factor for nosocomial infection due to breach of the cutaneous barrier.
Therefore, neonates who require intercostal drainage, especially those in high risk groups for nosocomial infection, may benefit from antibiotic prophylaxis.
However, injudicious antibiotic use carries the risk of promoting the emergence of resistant strains of micro-organisms or of altering the pattern of pathogens causing infection.
Objectives To determine the effect of prophylactic antibiotics compared to selective use of antibiotics on mortality and morbidity (especially septicaemia) in neonates undergoing placement of an intercostal catheter.
Search methods The standard search strategy of the Cochrane Neonatal Review Group was used to search the Cochrane Central Register of Controlled Trials (CENTRAL) ( The Cochrane Library 2011, Issue 5), MEDLINE (1948 to June 2011) and CINAHL (1982 to June 2011).
Selection criteria Randomised controlled trials or some types of non-randomised (that is, quasi-randomised) controlled trials of adequate quality in which either individual newborn infants or clusters of infants were randomised to receive prophylactic antibiotics versus placebo or no treatment.
Data collection and analysis We used the standard methods of the Cochrane Neonatal Review Group.
Main results We did not find any randomised controlled trials that met the eligibility criteria.