TRIP

New Guideline: Metformin Best to Control HbA1c (CME/CE)

MedPageToday, 2012

Combining more than two agents wasn't evaluated in this review, they added, and patients with persistent hyperglycemia despite oral therapy may eventually need insulin.
Qaseem and colleagues noted that low-quality or insufficient evidence made it difficult to draw conclusions about the comparative effectiveness of medications on all-cause and cardiovascular mortality, cardiovascular and cerebrovascular morbidity, and microvascular outcomes.
Qaseem A, et al "Oral pharmacologic treatment for type 2 diabetes mellitus: A clinical practice guideline from the American College of Physicians" Ann Intern Med 2012; 156: 218-231.
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