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What is the association, if any, between long-term proton pump inhibitors (PPIs) use and colorectal cancer.

TRIP Answers, 2012

What is the association, if any, between long-term proton pump inhibitors (PPIs) use and colorectal cancer.
What is the association, if any, between long-term proton pump inhibitors (PPIs) use and colorectal cancer.
We did however, find a number of case-control studies that evaluated the risk of colorectal cancer with the use of PPIs.
The first study (1) was a population-based case-control study  conducted within the Dutch Primary Care Information  database from 1996-2005.
Those cases with colorectal cancer were matched with up to 20 controls on age, gender, calendar time, and duration of follow-up prior to diagnosis.
Cumulative exposure to PPIs was assessed in the 5 yr prior to diagnosis with a 1-yr lag time analysis.
The odds of colorectal cancer were not increased among patients ever using PPIs compared with patients who never used PPIs (OR 0.85, 95% CI 0.63-1.16).
Also, the use of PPIs for >365 days was not associated with a greater risk of colorectal cancer (OR 0.79, 95% CI 0.44-1.41) compared with nonusers.
The odds of colorectal cancer in neither the right nor the left hemicolon were significantly increased in patients using PPIs.”
Larger numbers of long-term PPI users are needed to confirm the absence of a risk-increasing effect of long-term PPI exposure.”
A case-control study (3) with 641 participants who had been diagnosed with CRC between 2000 and 2003; the controls were randomly selected from enrollees and matched to cases on age, sex, and length of enrollment.